ArticleFrontiers in physiology2015
Dentin phosphophoryn in the matrix activates AKT and mTOR signaling pathway to promote preodontoblast survival and differentiation.
Article in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- DPP-Mediated Interaction of TAZ/β-Catenin Promotes the Differentiation of DPSCs into Odontoblasts.International journal of molecular sciences · 2026Article
- Transcriptome profiling of DPP stimulated DPSCs identifies the role of autophagy in odontogenic differentiation.Journal of structural biology · 2024Article
- DPP an extracellular matrix molecule induces Wnt5a mediated signaling to promote the differentiation of adult stem cells into odontogenic lineage.Scientific reports · 2024Article
- Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration.Cureus · 2022Review
- Dentine matrix metalloproteinases as potential mediators of dentine regeneration.European cells & materials · 2021Review
- DPP promotes odontogenic differentiation of DPSCs through NF-κB signaling.Scientific reports · 2021Article
- Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease.International journal of molecular sciences · 2021Review
- Dentin Phosphophoryn-Derived Peptide Promotes Odontoblast Differentiation In Vitro and Dentin Regeneration In Vivo.Materials (Basel, Switzerland) · 2021Article
- Unveiling diversity of stem cells in dental pulp and apical papilla using mouse genetic models: a literature review.Cell and tissue research · 2021Review
- Disentangling the complexity of low complexity proteins.Briefings in bioinformatics · 2020Review
- Conditional Knockout of Raptor/mTORC1 Results in Dentin Malformation.Frontiers in physiology · 2019Article
- The Role of Nephronectin on Proliferation and Differentiation in Human Dental Pulp Stem Cells.Stem cells international · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dentin phosphophoryn (DPP) is an extracellular matrix protein synthesized by odontoblasts. It is highly acidic and the phosphorylated protein possesses a strong affinity for calcium ions. Therefore, DPP in the extracellular matrix can promote hydroxyapatite nucleation and can regulate the size of the growing crystal. Besides its calcium binding property, DPP can initiate signaling functions from the ECM (Extracellular matrix). The signals that promote the cytodifferentiation of preodontoblasts to fully functional odontoblasts are not known. In this study, we demonstrate that preodontoblasts on a DPP matrix, generates mechanical and biochemical signals. This is initiated by the ligation of the integrins with the RGD containing DPP. The downstream biochemical response observed is the activation of the AKT(protein kinase B) and mTOR (mammalian target of rapamycin) signaling pathways leading to the activation of the transcription factor NF-κB (Nuclear factor κB). Terminal differentiation of the preodontoblasts was assessed by identifying phosphate and calcium deposits in the matrix using von Kossa and Alizarin red staining respectively. Identifying the signaling pathways initiated by DPP in the dentin matrix would help in devising strategies for dentin tissue engineering.
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