Evidence map›Paper›PMID 26300783›Full record

ArticleFrontiers in physiology2015

High-order finite element methods for cardiac monodomain simulations.

Kevin P Vincent, Matthew J Gonzales, Andrew K Gillette, Christopher T Villongco, Simone Pezzuto, Jeffrey H Omens, Michael J Holst, Andrew D McCulloch

Abstract read
In one paragraph

Article in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Forward-Solution Noninvasive Computational Arrhythmia Mapping: The VMAP Study.Circulation. Arrhythmia and electrophysiology · 2022
    Article
  3. Atlas-based methods for efficient characterization of patient-specific ventricular activation patterns.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kevin P VincentDepartment of Bioengineering, University of California San Diego La Jolla, CA, USA.
Matthew J GonzalesDepartment of Bioengineering, University of California San Diego La Jolla, CA, USA.
Andrew K GilletteDepartment of Mathematics, University of Arizona Tucson, AZ, USA.
Christopher T VillongcoDepartment of Bioengineering, University of California San Diego La Jolla, CA, USA.
Simone PezzutoDipartimento di Matematica, Politecnico di Milano Milano, Italy ; Center for Computational Medicine in Cardiology, Institute of Computational Science, Università della Svizzera italiana Lugano, Switzerland.
Jeffrey H OmensDepartment of Bioengineering, University of California San Diego La Jolla, CA, USA ; Department of Medicine, University of California San Diego La Jolla, CA, USA.
Michael J HolstDepartment of Mathematics, University of California San Diego La Jolla, CA, USA.
Andrew D McCullochDepartment of Bioengineering, University of California San Diego La Jolla, CA, USA ; Department of Medicine, University of California San Diego La Jolla, CA, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3M
National Biomedical Computation Resource - Competitive Revision SupplementP41GM103426 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMARO, ROMMIE E · 2012 to 2019
$14.0M
The Virtual Physiological Rat ProjectP50GM094503 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A · 2011 to 2015
$11.6M
Patient-Directed Computational Analysis of Atrial FibrillationR01HL122384 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WOUTER-JAN RAPPEL · 2015 to 2026
$5.3M
The Cardiac Atlas ProjectR01HL121754 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D., OMENS, JEFFREY H. · 2014 to 2023
$5.0M
Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8M
Integrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6M
Multi-scale Systems Model of Murine Heart FailureR01HL105242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BERS, DONALD M, MCCULLOCH, ANDREW D. · 2012 to 2016
$3.5M
Multi-Scale Modeling of the Failing Heart for Cardiac Rysynchronization TherapyR01HL096544 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D. · 2009 to 2013
$1.8M
Modeling and analysis of the mechanochemical processes that govern clathrin-mediated endocytosisR01GM132106 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANGAMANI, PADMINI · 2020 to 2024
$1.5M
NHLBI NIH HHS R01 HL096544NHLBI NIH HHS R01 HL105242NHLBI NIH HHS R01 HL121754NHLBI NIH HHS R01 HL122384NHLBI NIH HHS T32 HL105373NIBIB NIH HHS T32 EB009380NIGMS NIH HHS P41 GM103426NIGMS NIH HHS P50 GM094503NIGMS NIH HHS R01 GM132106NIGMS NIH HHS T32 GM007198
6 · The paper itself

Abstract

Computational modeling of tissue-scale cardiac electrophysiology requires numerically converged solutions to avoid spurious artifacts. The steep gradients inherent to cardiac action potential propagation necessitate fine spatial scales and therefore a substantial computational burden. The use of high-order interpolation methods has previously been proposed for these simulations due to their theoretical convergence advantage. In this study, we compare the convergence behavior of linear Lagrange, cubic Hermite, and the newly proposed cubic Hermite-style serendipity interpolation methods for finite element simulations of the cardiac monodomain equation. The high-order methods reach converged solutions with fewer degrees of freedom and longer element edge lengths than traditional linear elements. Additionally, we propose a dimensionless number, the cell Thiele modulus, as a more useful metric for determining solution convergence than element size alone. Finally, we use the cell Thiele modulus to examine convergence criteria for obtaining clinically useful activation patterns for applications such as patient-specific modeling where the total activation time is known a priori.

Indexed as

cardiac activation patterncell Thiele modulusfinite element analysismonodomain modelserendipity methods

Identifiers

PMID26300783
PMCPMC4525671

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.