Evidence map›Paper›PMID 26300772›Full record

ArticleFrontiers in aging neuroscience2015

Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder.

Panagiotis D Bamidis, Patrick Fissler, Sokratis G Papageorgiou, Vasiliki Zilidou, Evdokimos I Konstantinidis, Antonis S Billis, Evangelia Romanopoulou, Maria Karagianni, Ion Beratis, Angeliki Tsapanou and 17 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03899662 (A Neurophysiological Investigation of the Effectiveness of Web-based Exergaming Platform of Cognitive and Physical Training in Schizophrenic Patients), which is not on this map. Cited by 82 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 18 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03899662 nacompletednot on this mapstarted 2018, after this paper: background citation

A Neurophysiological Investigation of the Effectiveness of Web-based Exergaming Platform of Cognitive and Physical Training in Schizophrenic Patients

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2018 to 2019Enrolled4ConditionsSchizophreniaArmsCognitive Training, Physical Training
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 18 syntheses or guidelines pooled it, 183 citations in OpenAlex.

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  3. Exergaming for dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2024
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  11. Cognitive training for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2019
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 6 institutions in 2 countries.

Panagiotis D BamidisLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Patrick FisslerInstitute of Psychology and Pedagogy, Clinical and Biological Psychology, Ulm University, Ulm Germany.
Sokratis G PapageorgiouBehavioral Neurology and Neuropsychology Unit, 1st and 2nd Department of Neurology, Medical School, National Kapodistrian University of Athens Athens, Greece.
Vasiliki ZilidouLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Evdokimos I KonstantinidisLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Antonis S BillisLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Evangelia RomanopoulouLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Maria KaragianniLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece ; Greek Association of Alzheimer's Disease and Related Disorders, Thessaloniki Greece.
Ion BeratisBehavioral Neurology and Neuropsychology Unit, 1st and 2nd Department of Neurology, Medical School, National Kapodistrian University of Athens Athens, Greece.
Angeliki TsapanouBehavioral Neurology and Neuropsychology Unit, 1st and 2nd Department of Neurology, Medical School, National Kapodistrian University of Athens Athens, Greece.
Georgia TsilikopoulouBehavioral Neurology and Neuropsychology Unit, 1st and 2nd Department of Neurology, Medical School, National Kapodistrian University of Athens Athens, Greece.
Eirini GrigoriadouLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece ; Greek Association of Alzheimer's Disease and Related Disorders, Thessaloniki Greece.
Aristea LadasLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece ; Cognitive Psychology and Neuropsychology Lab, Department of Psychology, City College, The University of Sheffield International Faculty, Thessaloniki Greece.
Athina KyrillidouLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece ; Greek Association of Alzheimer's Disease and Related Disorders, Thessaloniki Greece.
Anthoula TsolakiLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece ; Greek Association of Alzheimer's Disease and Related Disorders, Thessaloniki Greece.
Christos FrantzidisLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Efstathios SidiropoulosLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Anastasios SiountasLaboratory of Medical Physics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Stavroula MatsiBehavioral Neurology and Neuropsychology Unit, 1st and 2nd Department of Neurology, Medical School, National Kapodistrian University of Athens Athens, Greece.
John PapatriantafyllouBehavioral Neurology and Neuropsychology Unit, 1st and 2nd Department of Neurology, Medical School, National Kapodistrian University of Athens Athens, Greece.
Eleni MargiotiBehavioral Neurology and Neuropsychology Unit, 1st and 2nd Department of Neurology, Medical School, National Kapodistrian University of Athens Athens, Greece.
Aspasia NikaBehavioral Neurology and Neuropsychology Unit, 1st and 2nd Department of Neurology, Medical School, National Kapodistrian University of Athens Athens, Greece.
Winfried SchleeDepartment of Psychiatry and Psychotherapy, University of Regensburg Regensburg, Germany.
Thomas ElbertClinical Psychology and Clinical Neuropsychology, University of Konstanz Konstanz, Germany.
Magda TsolakiGreek Association of Alzheimer's Disease and Related Disorders, Thessaloniki Greece ; 3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece.
Ana B VivasCognitive Psychology and Neuropsychology Lab, Department of Psychology, City College, The University of Sheffield International Faculty, Thessaloniki Greece.
Iris-Tatjana KolassaInstitute of Psychology and Pedagogy, Clinical and Biological Psychology, Ulm University, Ulm Germany.
Aristotle University of Thessaloniki · GRNational and Kapodistrian University of Athens · GRGreek Association of Alzheimer's Disease and Related Disorders · GRUniversität Ulm · DEUniversity of Konstanz · DEUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical as well as cognitive training interventions improve specific cognitive functions but effects barely generalize on global cognition. Combined physical and cognitive training may overcome this shortcoming as physical training may facilitate the neuroplastic potential which, in turn, may be guided by cognitive training. This study aimed at investigating the benefits of combined training on global cognition while assessing the effect of training dosage and exploring the role of several potential effect modifiers. In this multi-center study, 322 older adults with or without neurocognitive disorders (NCDs) were allocated to a computerized, game-based, combined physical and cognitive training group (n = 237) or a passive control group (n = 85). Training group participants were allocated to different training dosages ranging from 24 to 110 potential sessions. In a pre-post-test design, global cognition was assessed by averaging standardized performance in working memory, episodic memory and executive function tests. The intervention group increased in global cognition compared to the control group, p = 0.002, Cohen's d = 0.31. Exploratory analysis revealed a trend for less benefits in participants with more severe NCD, p = 0.08 (cognitively healthy: d = 0.54; mild cognitive impairment: d = 0.19; dementia: d = 0.04). In participants without dementia, we found a dose-response effect of the potential number and of the completed number of training sessions on global cognition, p = 0.008 and p = 0.04, respectively. The results indicate that combined physical and cognitive training improves global cognition in a dose-responsive manner but these benefits may be less pronounced in older adults with more severe NCD. The long-lasting impact of combined training on the incidence and trajectory of NCDs in relation to its severity should be assessed in future long-term trials.

Indexed as

agingcognitive trainingcombined interventiondementiaexergamesmild cognitive impairmentneurocognitive disorderphysical training

Identifiers

PMID26300772
PMCPMC4528297
OpenAlexW1561777872

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.