ArticleFrontiers in human neuroscience2015
On the existence of a generalized non-specific task-dependent network.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 3 of them syntheses that pooled it.
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Who cites it
103 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Non-literal language processing is jointly supported by the language and theory of mind networks: Evidence from a novel meta-analytic fMRI approach.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Pooled it
- Evidence for non-selective response inhibition in uncertain contexts revealed by combined meta-analysis and Bayesian analysis of fMRI data.Scientific reports · 2022Pooled it
- Brain regions that show repetition suppression and enhancement: A meta-analysis of 137 neuroimaging experiments.Human brain mapping · 2017Pooled it
- Trial
- Functional connectivity changes associated with fMRI neurofeedback of right inferior frontal cortex in adolescents with ADHD.NeuroImage · 2019Trial
- Real-time fMRI neurofeedback in adolescents with attention deficit hyperactivity disorder.Human brain mapping · 2017Trial
- The cerebellum specializes for language even in the absence of contralateral neocortical inputs.bioRxiv : the preprint server for biology · 2026Article
- Preserved topography, lateralization, selectivity, and functional connectivity of the language network in older brains.Nature communications · 2026Article
- The methodological foundations of lesion network mapping remain sound.bioRxiv : the preprint server for biology · 2026Article
- Action-mode subnetworks for decision-making, action control, and feedback.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Covariance-on-covariance regression.Biometrics · 2025Article
- Distinct neurochemical predictors for different phases of decision-making learning.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Decoding words during sentence production with ECoG reveals syntactic role encoding and structure-dependent temporal dynamics.Communications psychology · 2025Article
- The brain's action-mode network.Nature reviews. Neuroscience · 2025Review
- A data-driven latent variable approach to validating the research domain criteria framework.Nature communications · 2025Article
- Article
- Where in the brain is human intelligence?Cerebral circulation - cognition and behavior · 2025Article
- Linguistic inputs must be syntactically parsable to fully engage the language network.bioRxiv : the preprint server for biology · 2024Article
- The language network as a natural kind within the broader landscape of the human brain.Nature reviews. Neuroscience · 2024Review
- Default mode network shows distinct emotional and contextual responses yet common effects of retrieval demands across tasks.Human brain mapping · 2024Article
43 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper we suggest the existence of a generalized task-related cortical network that is up-regulated whenever the task to be performed requires the allocation of generalized non-specific cognitive resources, independent of the specifics of the task to be performed. We have labeled this general purpose network, the extrinsic mode network (EMN) as complementary to the default mode network (DMN), such that the EMN is down-regulated during periods of task-absence, when the DMN is up-regulated, and vice versa. We conceptualize the EMN as a cortical network for extrinsic neuronal activity, similar to the DMN as being a cortical network for intrinsic neuronal activity. The EMN has essentially a fronto-temporo-parietal spatial distribution, including the inferior and middle frontal gyri, inferior parietal lobule, supplementary motor area, inferior temporal gyrus. We hypothesize that this network is always active regardless of the cognitive task being performed. We further suggest that failure of network up- and down-regulation dynamics may provide neuronal underpinnings for cognitive impairments seen in many mental disorders, such as, e.g., schizophrenia. We start by describing a common observation in functional imaging, the close overlap in fronto-parietal activations in healthy individuals to tasks that denote very different cognitive processes. We now suggest that this is because the brain utilizes the EMN network as a generalized response to tasks that exceeds a cognitive demand threshold and/or requires the processing of novel information. We further discuss how the EMN is related to the DMN, and how a network for extrinsic activity is related to a network for intrinsic activity. Finally, we discuss whether the EMN and DMN networks interact in a common single brain system, rather than being two separate and independent brain systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.