ArticleFrontiers in behavioral neuroscience2015
Neuronal correlates of asocial behavior in a BTBR T (+) Itpr3(tf)/J mouse model of autism.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy.Nature communications · 2026Article
- Do pigs have altruistic behaviour based on cognitive empathy?BMC veterinary research · 2026Article
- Functional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism.Open biology · 2025Article
- Dysregulated HPA axis during postnatal developmental stages in the BTBR TNeuropsychopharmacology reports · 2025Article
- Sex-Differential Neural Circuits and Behavioral Responses for Empathy.Neuroscience bulletin · 2025Article
- Quantifying social distance using deep learning-based video analysis: results from the BTBR mouse model of autism.Frontiers in behavioral neuroscience · 2025Article
- Sociability versus empathy in adolescent mice: Different or distinctive?Learning and motivation · 2023Article
- Social Fear Affects Limbic System Neuronal Activity and Gene Expression.International journal of molecular sciences · 2022Article
- Anticipation of Scheduled Feeding in BTBR Mice Reveals Independence and Interactions Between the Light- and Food-Entrainable Circadian Clocks.Frontiers in integrative neuroscience · 2022Article
- Emotional contagion in nonhuman animals: A review.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2.Translational psychiatry · 2021Article
- Sodium phenylbutyrate reduces repetitive self-grooming behavior and rescues social and cognitive deficits in mouse models of autism.Psychopharmacology · 2021Article
- An insular view of the social decision-making network.Neuroscience and biobehavioral reviews · 2019Review
- MPS-IIIA mice acquire autistic behaviours with age.Journal of inherited metabolic disease · 2018Article
- The BTBR mouse model of idiopathic autism - Current view on mechanisms.Neuroscience and biobehavioral reviews · 2017Review
- The roots of empathy: Through the lens of rodent models.Neuroscience and biobehavioral reviews · 2017Review
- Serotonin neuron abnormalities in the BTBR mouse model of autism.Autism research : official journal of the International Society for Autism Research · 2017Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
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Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized, in part, by an inability to adequately respond to social cues. Patients diagnosed with ASD are often devoid of empathy and impaired in understanding other people's emotional perspective. The neuronal correlates of this impairment are not fully understood. Replicating such a behavioral phenotype in a mouse model of autism would allow us insight into the neuronal background of the problem. Here we tested BTBR T(+)Itpr3(tf)/J (BTBR) and c57BL/6J (B6) mice in two behavioral paradigms: the Transfer of Emotional Information test and the Social Proximity test. In both tests BTBR mice displayed asocial behavior. We analyzed c-Fos protein expression in several brain regions after each of these tests, and found that, unlike B6 mice, BTBR mice react to a stressed cagemate exposure in the Transfer of Emotional Information test with no increase of c-Fos expression in either the prefrontal cortex or the amygdala. However, after Social Proximity exposure we observed a strong increase in c-Fos expression in the CA3 field of the hippocampus and two hypothalamic regions of BTBR brains. This response was accompanied by a strong activation of periaqueductal regions related to defensiveness, which suggests that BTBR mice find unavoidable social interaction highly aversive.
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