ArticleFrontiers in systems neuroscience2015
Plasticity of cerebellar Purkinje cells in behavioral training of body balance control.
Article in Frontiers in systems neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- A novel behavioral paradigm using mice to study predictive postural control.Frontiers in neuroscience · 2026Article
- The First of Us:bioRxiv : the preprint server for biology · 2025Article
- The Relationship between Early Exposure to General Anesthesia and Neurobehavioral Deficits.Developmental neuroscience · 2025Review
- Social Relationship as a Factor for the Development of Stress Incubation in Adult Mice.Frontiers in behavioral neuroscience · 2022Article
- Hypergravity-induced malfunction was moderated by the regulation of NMDA receptors in the vestibular nucleus.Scientific reports · 2021Article
- Cathodal Cerebellar tDCS Combined with Visual Feedback Improves Balance Control.Cerebellum (London, England) · 2020Article
- Simple spike dynamics of Purkinje cells in the macaque vestibulo-cerebellum during passive whole-body self-motion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A unified internal model theory to resolve the paradox of active versus passive self-motion sensation.eLife · 2017Article
- Propofol Exposure in Early Life Induced Developmental Impairments in the Mouse Cerebellum.Frontiers in cellular neuroscience · 2017Article
- "Cerebellar Challenge" for Older Adults: Evaluation of a Home-Based Internet Intervention.Frontiers in aging neuroscience · 2017Article
- A comparative approach to cerebellar function: insights from electrosensory systems.Current opinion in neurobiology · 2016Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural responses to sensory inputs caused by self-generated movements (reafference) and external passive stimulation (exafference) differ in various brain regions. The ability to differentiate such sensory information can lead to movement execution with better accuracy. However, how sensory responses are adjusted in regard to this distinguishability during motor learning is still poorly understood. The cerebellum has been hypothesized to analyze the functional significance of sensory information during motor learning, and is thought to be a key region of reafference computation in the vestibular system. In this study, we investigated Purkinje cell (PC) spike trains as cerebellar cortical output when rats learned to balance on a suspended dowel. Rats progressively reduced the amplitude of body swing and made fewer foot slips during a 5-min balancing task. Both PC simple (SSs; 17 of 26) and complex spikes (CSs; 7 of 12) were found to code initially on the angle of the heads with respect to a fixed reference. Using periods with comparable degrees of movement, we found that such SS coding of information in most PCs (10 of 17) decreased rapidly during balance learning. In response to unexpected perturbations and under anesthesia, SS coding capability of these PCs recovered. By plotting SS and CS firing frequencies over 15-s time windows in double-logarithmic plots, a negative correlation between SS and CS was found in awake, but not anesthetized, rats. PCs with prominent SS coding attenuation during motor learning showed weaker SS-CS correlation. Hence, we demonstrate that neural plasticity for filtering out sensory reafference from active motion occurs in the cerebellar cortex in rats during balance learning. SS-CS interaction may contribute to this rapid plasticity as a form of receptive field plasticity in the cerebellar cortex between two receptive maps of sensory inputs from the external world and of efference copies from the will center for volitional movements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.