ReviewFrontiers in systems neuroscience2015
Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states.
Review in Frontiers in systems neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function.Hippocampus · 2025Article
- Role of Hypothalamic CRH Neurons in Regulating the Impact of Stress on Memory and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A hypothalamic circuit mechanism underlying the impact of stress on memory and sleep.bioRxiv : the preprint server for biology · 2024Article
- Comprehensive analysis of locomotion dynamics in the protochordate Ciona intestinalis reveals how neuromodulators flexibly shape its behavioral repertoire.PLoS biology · 2022Article
- Arcuate NPY is involved in salt-induced hypertension via modulation of paraventricular vasopressin and brain-derived neurotrophic factor.Journal of cellular physiology · 2022Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus.eLife · 2020Article
- Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles.Science (New York, N.Y.) · 2020Article
- Neural and Hormonal Control of Sexual Behavior.Endocrinology · 2020Review
- BOLD differences normally attributed to inhibitory control predict symptoms, not task-directed inhibitory control in ADHD.Journal of neurodevelopmental disorders · 2020Article
- Thirst and Drinking Paradigms: Evolution from Single Factor Effects to Brainwide Dynamic Networks.Nutrients · 2019Review
- Hypothalamic Inflammation at a Crossroad of Somatic Diseases.Cellular and molecular neurobiology · 2019Review
- Systemic Glucose Administration Alters Water Diffusion and Microvascular Blood Flow in Mouse Hypothalamic Nuclei - An fMRI Study.Frontiers in neuroscience · 2019Article
- Identification of discrete, intermingled hypocretin neuronal populations.The Journal of comparative neurology · 2018Article
- The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders.Psychopharmacology · 2018Review
- A tale of two circuits: CCKNeuroscience · 2017Article
- Algorithms for survival: a comparative perspective on emotions.Nature reviews. Neuroscience · 2017Review
- Memory of recent oxygen experience switches pheromone valence inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Current Evidence for a Role of Neuropeptides in the Regulation of Autophagy.BioMed research international · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major question in systems neuroscience is how a single population of neurons can interact with the rest of the brain to orchestrate complex behavioral states. The hypothalamus contains many such discrete neuronal populations that individually regulate arousal, feeding, and drinking. For example, hypothalamic neurons that express hypocretin (Hcrt) neuropeptides can sense homeostatic and metabolic factors affecting wakefulness and orchestrate organismal arousal. Neurons that express agouti-related protein (AgRP) can sense the metabolic needs of the body and orchestrate a state of hunger. The organum vasculosum of the lamina terminalis (OVLT) can detect the hypertonicity of blood and orchestrate a state of thirst. Each hypothalamic population is sufficient to generate complicated behavioral states through the combined efforts of distinct efferent projections. The principal challenge to understanding these brain systems is therefore to determine the individual roles of each downstream projection for each behavioral state. In recent years, the development and application of temporally precise, genetically encoded tools has greatly improved our understanding of the structure and function of these neural systems. This review will survey recent advances in our understanding of how these individual hypothalamic populations can orchestrate complicated behavioral states due to the combined efforts of individual downstream projections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.