ReviewFrontiers in cellular neuroscience2015
Sympathoadrenergic modulation of hematopoiesis: a review of available evidence and of therapeutic perspectives.
Review in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Rap1A, Rap1B, and β-Adrenergic Signaling in Autologous HCT: A Randomized Controlled Trial of Propranolol.The Yale journal of biology and medicine · 2022Trial
- Diosgenin-loaded niosomes ameliorate cadmium-induced neurotoxicity and endocrine disruption in female rats through modulation of oxidative stress, apoptosis, and inflammatory markers.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Intermittent fasting enhances cancer therapyWorld journal of clinical oncology · 2026Review
- Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance.Cell death & disease · 2025Review
- The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms.Journal of neuroinflammation · 2025Review
- Adrenergic orchestration of immune cell dynamics in response to cardiac stress.Journal of molecular and cellular cardiology · 2024Review
- Association between changes in depressive symptoms and risk of anemia: from the China Health and Retirement longitudinal study.Archives of public health = Archives belges de sante publique · 2024Article
- Central regulation of stress-evoked peripheral immune responses.Nature reviews. Neuroscience · 2023Review
- Relationship between depressive symptoms and anemia among the middle-aged and elderly: a cohort study over 4-year period.BMC psychiatry · 2023Article
- Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis.Journal of leukocyte biology · 2022Review
- Heart-brain interactions in cardiac and brain diseases: why sex matters.European heart journal · 2022Review
- Understanding the role of dopamine in cancer: past, present and future.Carcinogenesis · 2022Review
- Immune Cell Plasticity in Inflammation: Insights into Description and Regulation of Immune Cell Phenotypes.Cells · 2022Review
- Red Blood Cell Distribution Width in Heart Failure: Pathophysiology, Prognostic Role, Controversies and Dilemmas.Journal of clinical medicine · 2022Review
- The Brain: Is it a Next Frontier to Better Understand the Regulation and Control of Hematopoiesis for Future Modulation and Treatment?Stem cell reviews and reports · 2021Article
- Review
- Article
- Article
- Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- Dopaminergic Pathways in Obesity-Associated Inflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Innervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradrenaline and possibly also dopamine, which act on adrenoceptors and dopaminergic receptors (DR) expressed on hematopoietic cells and affect cell survival, proliferation, migration and engraftment ability. Remarkably, dysregulation of adrenergic fibers to the BM is associated with hematopoietic disturbances and myeloproliferative disease. Several adrenergic and dopaminergic agents are already in clinical use for non-hematological indications and with a usually favorable risk-benefit profile, and are therefore potential candidates for non-conventional modulation of hematopoiesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.