Evidence map›Paper›PMID 26300719›Full record

ArticleFrontiers in neuroscience2015

Variations of high frequency parameter of heart rate variability following osteopathic manipulative treatment in healthy subjects compared to control group and sham therapy: randomized controlled trial.

Nuria Ruffini, Giandomenico D'Alessandro, Nicolò Mariani, Alberto Pollastrelli, Lucia Cardinali, Francesco Cerritelli

4 registry-linked trialsOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 50 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 5 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01908920 nacompletednot on this map

Osteopathic Manipulative Treatment Effects on High Frequency Parameters in Healthy Subjects

TypeinterventionalSponsorEuropean Institute for Evidence Based Osteopathic MedicineRan2013 to 2013Enrolled60ConditionsHealthy Subject, Heart Rate VariabilityArmsOsteopathic manipulative treatment, SHAM, CONTROL
NCT04004741 nacompletednot on this mapstarted 2019, after this paper: background citation

Effects of Osteopathic Manipulative Therapy on Arrhythmias

TypeinterventionalSponsorNew York Institute of TechnologyRan2019 to 2022Enrolled42ConditionsCardiac ArrhythmiaArmsOsteopathic Manipulative Treatment, Light Touch Therapy
NCT04127617 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Neurogenic Bowel Dysfunction: Evaluation of the Effects of Osteopathic Manipulative Treatment in People With Central Nervous System Injury

TypeinterventionalSponsorUniversity of Turin, ItalyRan2019 to 2022Enrolled70ConditionsCentral Nervous System Injury, Neurogenic Bowel DysfunctionArmsOsteopathic Manipulative Treatment, Nursing Educational Care
NCT07670806 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of an Osteopathic Intervention Protocol on the Parasympathetic System on Stress and Anxiety in Young Adults: a Randomized Clinical Trial

TypeinterventionalSponsorEscola Superior de Tecnologia da Saúde do PortoRan2026 to 2026Enrolled30ConditionsStress, AnxietyArmsFourth Ventricle Technique, Suboccipital Decompression, Diaphragm Myofascial Release Technique, Sacral Rock, Sham Cranial Listening
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Association of non-linear dynamics of heart rate variability with all-cause mortality in patients with sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Impact of Osteopathic Techniques on Autonomic Regulation: A Study of Heart Rate Variability in Healthy Adults.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nuria RuffiniResearch Department, Accademia Italiana Osteopatia Tradizionale Pescara, Italy ; Clinical-based Human Research Department, Centre for Osteopathic Medicine Collaboration Pescara, Italy.
Giandomenico D'AlessandroResearch Department, Accademia Italiana Osteopatia Tradizionale Pescara, Italy ; Clinical-based Human Research Department, Centre for Osteopathic Medicine Collaboration Pescara, Italy.
Nicolò MarianiResearch Department, Accademia Italiana Osteopatia Tradizionale Pescara, Italy.
Alberto PollastrelliResearch Department, Accademia Italiana Osteopatia Tradizionale Pescara, Italy.
Lucia CardinaliResearch Department, Accademia Italiana Osteopatia Tradizionale Pescara, Italy ; Clinical-based Human Research Department, Centre for Osteopathic Medicine Collaboration Pescara, Italy.
Francesco CerritelliClinical-based Human Research Department, Centre for Osteopathic Medicine Collaboration Pescara, Italy.
Accademia Italiana Medicina Osteopatica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextHeart Rate Variability (HRV) indicates how heart rate changes in response to inner and external stimuli. HRV is linked to health status and it is an indirect marker of the autonomic nervous system (ANS) function.

objectiveTo investigate the influence of osteopathic manipulative treatment (OMT) on cardiac autonomic modulation in healthy subjects, compared with sham therapy and control group.

methodsSixty-six healthy subjects, both male and female, were included in the present 3-armed randomized placebo controlled within subject cross-over single blinded study. Participants were asymptomatic adults (26.7 ± 8.4 y, 51% male, BMI 18.5 ± 4.8), both smokers and non-smokers and not on medications. At enrollment subjects were randomized in three groups: A, B, C. Standardized structural evaluation followed by a patient need-based osteopathic treatment was performed in the first session of group A and in the second session of group B. Standardized evaluation followed by a protocoled sham treatment was provided in the second session of group A and in the first session of group B. No intervention was performed in the two sessions of group C, acting as a time-control. The trial was registered on clinicaltrials.gov identifier: NCT01908920. MAIN OUTCOMES MEASURES: HRV was calculated from electrocardiography before, during and after the intervention, for a total amount time of 25 min and considering frequency domain as well as linear and non-linear methods as outcome measures.

resultsOMT engendered a statistically significant increase of parasympathetic activity, as shown by High Frequency power (p < 0.001), expressed in normalized and absolute unit, and possibly decrease of sympathetic activity, as revealed by Low Frequency power (p < 0.01); results also showed a reduction of Low Frequency/High Frequency ratio (p < 0.001) and Detrended fluctuation scaling exponent (p < 0.05).

conclusionsFindings suggested that OMT can influence ANS activity increasing parasympathetic function and decreasing sympathetic activity, compared to sham therapy and control group.

Indexed as

autonomic nervous systemhealthy subjectsheart rate variabilityhigh frequencyosteopathic medicineparasympathetic effectsmoking

Identifiers

PMID26300719
PMCPMC4523739
OpenAlexW1525195494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.