Evidence map›Paper›PMID 26300676›Full record

ArticleCurrent oncology (Toronto, Ont.)2015

In serum, higher parathyroid hormone but not lower vitamin D is associated with oral squamous cell carcinoma.

H Zhang, H Lu, C Shrestha, Y Feng, Y Li, J Peng, Y Li, Z Xie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

H ZhangDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
H LuDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
C ShresthaDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
Y FengDepartment of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, PRC;
Y LiDepartment of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, PRC;
J PengDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
Y LiStomatological Hospital of Xiangtan, Xiangtan, PRC.
Z XieDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, PRC;
Central South University · CNSecond Xiangya Hospital of Central South University · CNXiangyang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVitamin D and calcium are known to regulate differentiation and proliferation of keratinocytes; they might potentially have a role in suppressing carcinogenesis in squamous epithelium. Serum parathyroid hormone (pth) is a sensitive indicator of calcium and vitamin D deficiency, and 25-hydroxyvitamin D [25(OH)D] is an established marker of vitamin D status.

methodsTo determine whether levels of 25(OH)D, calcium, or pth in serum are associated with oral squamous cell carcinoma (oscc), we examined those parameters in serum collected from 70 patients with oscc and from an equal number of matched control subjects.

resultsThe results showed that intact pth was significantly higher in serum from oscc patients than in serum from control subjects. However, we observed no significant differences in 25(OH)D or calcium in serum from oscc patients and from control subjects.

conclusionsWe conclude that higher serum pth, but not lower serum vitamin D or calcium, is associated with oscc.

Indexed as

25-hydroxyvitamin DcalciumOral squamous cell carcinomaparathyroid hormone

Identifiers

PMID26300676
PMCPMC4530823
OpenAlexW1498387550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.