ReviewVascular health and risk management2015
Secondary stroke prevention: challenges and solutions.
Review in Vascular health and risk management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 3 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence.Brain and behavior · 2025Pooled it
- A systematic review of alterations in brain activation and intensity following stroke: implications for integration and functional outcomes.Frontiers in neurology · 2025Pooled it
- The effect of the Mediterranean diet on health outcomes in post-stroke adults: a systematic literature review of intervention trials.European journal of clinical nutrition · 2023Pooled it
- Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Swallowing Function in Post-stroke Dysphagia: A Randomized Controlled Study.Translational stroke research · 2026Trial
- The effects of intravenous laser irradiation of blood with red and blue light on stroke risk biomarkers and neurological function: a double blind randomized controlled trial.Lasers in medical science · 2025Trial
- The Post-Stroke Checklist: longitudinal use in routine clinical practice during first year after stroke.BMC cardiovascular disorders · 2024Trial
- Artificial Intelligence Limb Rehabilitation System on Account of Virtual Reality Technology on Long-Term Health Management of Stroke Patients in the Context of the Internet.Computational and mathematical methods in medicine · 2022Trial
- Effect of acupuncture on ischemic stroke patients with hypertension: a randomized clinical trail.Frontiers in neurologyTrial
- Article
- The relationship between inflammatory markers and the severity and prognosis of neurological dysfunction in stroke patients.BMC neurology · 2026Article
- Plasma albumin and other indicators as risk factors for delayed neurocognitive recovery in elderly patients undergoing orthopedic surgery.BMC surgery · 2026Article
- Article
- From Stroke to Strength: The Role of Exercise in Managing Hypertension and Lipid Profiles.Neurology and therapy · 2026Review
- Population-Level Digital Stroke Surveillance: Building a Fair and Accurate ICD-10 Detection Model.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Real-time phase-contrast MRI can be used to quantify cerebrovascular reserve capacity - a comparative study to neurovascular ultrasound in healthy subjects.Neuroimage. Reports · 2026Article
- Introducing and Validating a Minimum Data Set and Core Functionalities for Remote Poststroke Home Monitoring: "A Cross-Sectional Study".Health science reports · 2026Article
- Global expert consensus on the importance of secondary stroke prevention: challenges, care coordination and unmet needs for non-cardioembolic ischaemic stroke survivors.European stroke journal · 2026Article
- Anti-N-methyl-ᴅ-aspartate receptor encephalitis preceding stroke: report of an unusual case with literature review.Encephalitis (Seoul, Korea) · 2025Article
- Association Between Physical Activity and Stroke Recurrence: A Cross-Sectional Study.Florence Nightingale journal of nursing · 2025Article
- Barriers to medication adherence for secondary stroke prevention in rural communities in Cameroon: a qualitative study.BMC primary care · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Stroke is the leading cause of disability in the USA and a major cause of mortality worldwide. One out of four strokes is recurrent. Secondary stroke prevention starts with deciphering the most likely stroke mechanism. In general, one of the main goals in stroke reduction is to control vascular risk factors such as hypertension, diabetes, dyslipidemia, and smoking cessation. Changes in lifestyle like a healthy diet and aerobic exercise are also recommended strategies. In the case of cardioembolism due to atrial fibrillation, mechanical valves, or cardiac thrombus, anticoagulation is the mainstay of therapy. The role of anticoagulation is less evident in the case of bioprosthetic valves, patent foramen ovale, and dilated cardiomyopathy with low ejection fraction. Strokes due to larger artery atherosclerosis account for approximately a third of all strokes. In the case of symptomatic extracranial carotid stenosis, surgical intervention as close as possible in time to the index event seems highly beneficial. In the case of intracranial large artery atherosclerosis, the best medical therapy consists of antiplatelets, high-dose statins, aggressive controls of vascular risk factors, and lifestyle modifications, with no role for intracranial arterial stenting or angioplasty. For patients with small artery occlusion (ie, lacunar stroke), the therapy is similar to that used in patients with intracranial large artery atherosclerosis. Despite the constant new evidence on how to best treat patients who have suffered a stroke, the risk of stroke recurrence remains unacceptably high, thus evidencing the need for novel therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.