ArticleNeuropsychiatric disease and treatment2015
Relationship between cobalamin deficiency and delirium in elderly patients undergoing cardiac surgery.
Article in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Micronutrient Deficiency and Its Potential Role in Delirium Onset in Older Adults: A Systematic Review.The journal of nutrition, health & aging · 2023Pooled it
- Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- Associations between polygenic risk scores for Alzheimer's disease and postoperative delirium risk.Journal of Alzheimer's disease : JAD · 2026Article
- Burden of delirium on mortality and healthcare resource utilization in geriatric patients hospitalized for inflammatory bowel disease.Proceedings (Baylor University. Medical Center) · 2024Article
- Evaluating Nutritional Risk Factors for Delirium in Intensive-Care-Unit Patients: Present Insights and Prospects for Future Research.Clinics and practice · 2023Review
- Acute Stereotypic Behavior: Expanding the Spectrum of Movement Disorders Attributed to Vitamin B12 Deficiency.Movement disorders clinical practice · 2020Article
- Cobalamin Deficiency in the Elderly.Mediterranean journal of hematology and infectious diseases · 2020Review
- The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium.Neuropsychiatric disease and treatment · 2019Article
- The major risk factors for delirium in a clinical setting.Neuropsychiatric disease and treatment · 2016Article
- Is cobalamin deficiency associated with increased risk of all subtypes of postoperative delirium?Neuropsychiatric disease and treatment · 2016Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDelirium is common after cardiac surgery and is independently associated with increased morbidity, mortality, prolonged hospital stays, and higher costs. Cobalamin (vitamin B12) deficiency is a common cause of neuropsychiatric symptoms and affects up to 40% of elderly people. The relationship between cobalamin deficiency and the occurrence of delirium after cardiac surgery has not been examined in previous studies. We examined the relationship between cobalamin deficiency and delirium in elderly patients undergoing coronary artery bypass grafting (CABG) surgery. MATERIAL AND
methodsA total of 100 patients with cobalamin deficiency undergoing CABG were enrolled in this retrospective study. Control group comprised 100 patients without cobalamin deficiency undergoing CABG. Patients aged 65 years or over were included. Diagnosis of delirium was made using Intensive Care Delirium Screening Checklist. Delirium severity was measured using the Delirium Rating Scale-revised-98.
resultsPatients with cobalamin deficiency had a significantly higher incidence of delirium (42% vs 26%; P=0.017) and higher delirium severity scores (16.5±2.9 vs 15.03±2.48; P=0.034) than patients without cobalamin deficiency. Cobalamin levels were significantly lower in patients with delirium than patients without delirium (P=0.004). Delirium severity score showed a moderate correlation with cobalamin levels (ρ=-0.27; P=0.024). Logistic regression analysis demonstrated that cobalamin deficiency was independently associated with postoperative delirium (OR 1.93, 95% CI 1.03-3.6, P=0.038).
conclusionThe results of our study suggest that cobalamin deficiency may be associated with increased risk of delirium in patients undergoing CABG. In addition, we found that preoperative cobalamin levels were associated with the severity of delirium. This report highlights the importance of investigation for cobalamin deficiency in patients undergoing cardiac surgery, especially in the elderly.
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