ReviewPigment cell & melanoma research2015
Genetics of melanocytic nevi.
Review in Pigment cell & melanoma research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 176 citations in OpenAlex.
- [Melanocytomas : Intermediate melanocytic neoplasms with distinct morphology and molecular background].Pathologie (Heidelberg, Germany) · 2026Review
- Precision Medicine in Dermatology: MEK Inhibition and MAPK Pathway Modulation for Congenital Melanocytic Nevi.Biomedicines · 2026Review
- Nodal Cellular Blue Nevus in Sentinel Lymph Node Biopsy: A Case Report With Emphasis on Avoiding Misdiagnosis of This Important Mimicker of Metastatic Melanoma.Journal of cutaneous pathology · 2026Article
- Single-cell transcriptomic profiling of halo nevi and normal nevi reveals CD8Frontiers in immunology · 2026Article
- Identifying suspicious naevi with dermoscopy via variational autoencoder auxiliary generative classifiers.Physical and engineering sciences in medicine · 2025Article
- Identification of biomarkers related to the progression of cutaneous melanoma and construction of survival prognosis model.Discover oncology · 2025Article
- Melanoma in Women of Reproductive Age: From Awareness and Prevention to Pregnancy-Associated Management.Cancers · 2025Review
- Characterization of Oral Melanocytic Nevi in Sun-Exposed and Sun-Protected Regions.Oral diseases · 2025Article
- Crosstalk in Skin: Loss of Desmoglein 1 in Keratinocytes Inhibits BRAFThe Journal of investigative dermatology · 2025Article
- An overview of benefits and risks of chronic melanocortin-1 receptor activation.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Review
- Melanocytoma of the eyelid: Case report and introduction of new nomenclature.American journal of ophthalmology case reports · 2024Article
- Assessment of RAS-RAF-MAPK Pathway Mutation Status in Healthy Skin, Benign Nevi, and Cutaneous Melanomas: Pilot Study Using Droplet Digital PCR.International journal of molecular sciences · 2024Article
- The 5th Edition of the World Health Organization Classification of Tumours of the Eye and Orbit.Ocular oncology and pathology · 2023Article
- Article
- Review
- Stardust Pattern as Evolution of Pigmented Spitz Nevi During Childhood.Dermatology practical & conceptual · 2023Article
- Cell-intrinsic melanin fails to protect melanocytes from ultraviolet-mutagenesis in the absence of epidermal melanin.Pigment cell & melanoma research · 2023Article
- Analyzing the Spatial Randomness in the Distribution of Acquired Melanocytic Neoplasms.The Journal of investigative dermatology · 2022Article
- Laser treatment of benign melanocytic lesion: a review.Lasers in medical science · 2022Review
- Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Melanocytic nevi are a benign clonal proliferation of cells expressing the melanocytic phenotype, with heterogeneous clinical and molecular characteristics. In this review, we discuss the genetics of nevi by salient nevi subtypes: congenital melanocytic nevi, acquired melanocytic nevi, blue nevi, and Spitz nevi. While the molecular etiology of nevi has been less thoroughly studied than melanoma, it is clear that nevi and melanoma share common driver mutations. Acquired melanocytic nevi harbor oncogenic mutations in BRAF, which is the predominant oncogene associated with melanoma. Congenital melanocytic nevi and blue nevi frequently harbor NRAS mutations and GNAQ mutations, respectively, while Spitz and atypical Spitz tumors often exhibit HRAS and kinase rearrangements. These initial 'driver' mutations are thought to trigger the establishment of benign nevi. After this initial phase of the cell proliferation, a senescence program is executed, causing termination of nevi growth. Only upon the emergence of additional tumorigenic alterations, which may provide an escape from oncogene-induced senescence, can malignant progression occur. Here, we review the current literature on the pathobiology and genetics of nevi in the hope that additional studies of nevi promise to inform our understanding of the transition from benign neoplasm to malignancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.