ArticleNeuropathology and applied neurobiology2016
Audit of practice in sudden unexpected death in epilepsy (SUDEP) post mortems and neuropathological findings.
Article in Neuropathology and applied neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Sudden death in epilepsy: There is room for intracranial pressure.Brain and behavior · 2020Pooled it
- Systematic Review of the Genetics of Sudden Unexpected Death in Epilepsy: Potential Overlap With Sudden Cardiac Death and Arrhythmia-Related Genes.Journal of the American Heart Association · 2020Pooled it
- Identifying patterns of neuropathological diagnoses in medico-legal autopsies - A latent class analysis of 1270 neuropathologically examined cases from Finland.Forensic science, medicine, and pathology · 2026Article
- Impact of organ sampling for forensic pathology: should heart and brain be retained whole?Forensic science, medicine, and pathology · 2026Article
- Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history.Acta neuropathologica · 2024Article
- Epilepsy-associated death in the Southwestern Ontario: A clinicopathological correlation study.Brain pathology (Zurich, Switzerland) · 2023Article
- Sudden unexpected death in epilepsy: Investigation of autopsy-based studies.Frontiers in neurology · 2023Article
- Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths.Neuropathology and applied neurobiology · 2022Article
- Analysis of forensic autopsy cases associated with epilepsy: Comparison between sudden unexpected death in epilepsy (SUDEP) and not-SUDEP groups.Frontiers in neurology · 2022Article
- Raphe and ventrolateral medulla proteomics in epilepsy and sudden unexpected death in epilepsy.Brain communications · 2022Article
- Confirmation of Cause of Death Via Comprehensive Autopsy and Whole Exome Molecular Sequencing in People With Epilepsy and Sudden Unexpected Death.Journal of the American Heart Association · 2021Article
- Review: Neuropathology findings in autonomic brain regions in SUDEP and future research directions.Autonomic neuroscience : basic & clinical · 2021Review
- Proteomics and Transcriptomics of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Patients.Neurology · 2021Article
- Seizure-related deaths in children: The expanding spectrum.Epilepsia · 2021Article
- Neuropathology in the North American sudden unexpected death in epilepsy registry.Brain communications · 2021Article
- Article
- Manner of Death Certification After Significant Emotional Stress: An Inter-Rater Variability Study and Review of the Literature.Academic forensic pathology · 2018Article
- Review: The past, present and future challenges in epilepsy-related and sudden deaths and biobanking.Neuropathology and applied neurobiology · 2018Review
- Dead in the Night: Sleep-Wake and Time-Of-Day Influences on Sudden Unexpected Death in Epilepsy.Frontiers in neurology · 2018Review
- Neuropathology of SUDEP: Role of inflammation, blood-brain barrier impairment, and hypoxia.Neurology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 3 countries.
Funding
Abstract
aimsSudden unexpected death in epilepsy (SUDEP) is one of the leading causes of death in people with epilepsy. For classification of definite SUDEP, a post mortem (PM), including anatomical and toxicological examination, is mandatory to exclude other causes of death. We audited PM practice as well as the value of brain examination in SUDEP.
methodsWe reviewed 145 PM reports in SUDEP cases from four UK neuropathology centres. Data were extracted for clinical epilepsy details, circumstances of death and neuropathological findings.
resultsMacroscopic brain abnormalities were identified in 52% of cases. Mild brain swelling was present in 28%, and microscopic pathologies relevant to cause or effect of seizures were seen in 89%. Examination based on whole fixed brains (76.6% of all PMs), and systematic regional sampling was associated with higher detection rates of underlying pathology (P < 0.01). Information was more frequently recorded regarding circumstances of death and body position/location than clinical epilepsy history and investigations.
conclusionOur findings support the contribution of examination of the whole fixed brain in SUDEP, with high rates of detection of relevant pathology. Availability of full clinical epilepsy-related information at the time of PM could potentially further improve detection through targeted tissue sampling. Apart from confirmation of SUDEP, complete neuropathological examination contributes to evaluation of risk factors as well as helping to direct future research into underlying causes.
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