ArticleArthritis research & therapy2015
Studies on ageing and the severity of radiographic joint damage in rheumatoid arthritis.
Article in Arthritis research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis.Journal of orthopaedic surgery and research · 2025Article
- Review
- Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis.Journal of inflammation research · 2021Article
- Synovitis in rheumatoid arthritis detected by grey scale ultrasound predicts the development of erosions over the next three years.Rheumatology (Oxford, England) · 2020Article
- Characterizing hand and wrist ultrasound pattern in primary Sjögren's syndrome: a case-control study.Clinical rheumatology · 2020Article
- Improvement of symptoms in clinically suspect arthralgia and resolution of subclinical joint inflammation: a longitudinal study in patients that did not progress to clinical arthritis.Arthritis research & therapy · 2020Article
- Pseudoerosions of Hands and Feet in Rheumatoid Arthritis: Anatomic Concepts and Redefinition.Journal of clinical medicine · 2019Article
- Motion analysis of the wrist joints in Chinese rheumatoid arthritis patients: a cross-sectional study.BMC musculoskeletal disorders · 2018Article
- Are MRI-detected erosions specific for RA? A large explorative cross-sectional study.Annals of the rheumatic diseases · 2018Article
- Circulating Semaphorin 4D as a Marker for Predicting Radiographic Progression in Patients with Rheumatoid Arthritis.Disease markers · 2018Article
- The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical.Arthritis research & therapy · 2017Article
- Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis.BMC musculoskeletal disorders · 2017Article
- HLA-DRB1 Amino Acid Positions 11/13, 71, and 74 Are Associated With Inflammation Level, Disease Activity, and the Health Assessment Questionnaire Score in Patients With Inflammatory Polyarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Age affects joint space narrowing in patients with early active rheumatoid arthritis.RMD open · 2016Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe western population is ageing. It is unknown whether age at diagnosis affects the severity of Rheumatoid Arthritis (RA), we therefore performed the present study.
method1,875 RA-patients (7,219 radiographs) included in five European and North-American cohorts (Leiden-EAC, Wichita, Umeå, Groningen and Lund) were studied on associations between age at diagnosis and joint damage severity. In 698 Leiden RA-patients with 7-years follow-up it was explored if symptom duration, anti-citrullinated-peptide-antibodies (ACPA), swollen joint count (SJC) and C-reactive-protein (CRP) mediated the association of age with joint damage. Fifty-six other RA-patients of the EAC-cohort underwent baseline MRIs of wrist, MCP and MTP-joints; MRI-inflammation (RAMRIS-synovitis plus bone marrow edema) was also evaluated in mediation analyses. Linear regression and multivariate normal regression models were used.
resultsAnalysis on the five cohorts and the Leiden-EAC separately revealed 1.026-fold and 1.034-fold increase of radiographic joint damage per year increase in age (β=1.026, 1.034, both p<0.001); this effect was present at baseline and persisted over time. Age correlated stronger with baseline erosion-scores compared to joint space narrowing (JSN)-scores (r=0.38 versus 0.29). Symptom duration, ACPA, SJC and CRP did not mediate the association of age with joint damage severity. Age was significantly associated with the MRI-inflammation-score after adjusting for CRP and SJC (β=1.018, p=0.027). The association of age with joint damage (β=1.032, p=0.004) decreased after also including the MRI-inflammation-score (β=1.025, p=0.021), suggesting partial mediation.
conclusionRA-patients presenting at higher age have more severe joint damage; this might be partially explained by more severe MRI-detected inflammation at higher age.
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