SynthesisScientific reports2015
Parity and Cardiovascular Disease Mortality: a Dose-Response Meta-Analysis of Cohort Studies.
Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Are pregnancy and parity associated with telomere length? A systematic review.BMC pregnancy and childbirth · 2023Pooled it
- Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review.BMJ (Clinical research ed.) · 2020Pooled it
- Parity and serum lipid levels: a cross-sectional study in chinese female adults.Scientific reports · 2016Trial
- Parity and heart failure risk in diabetic women with coronary artery disease: a multicentre cohort study.ESC heart failure · 2026Article
- Number of Live Births as a Protective Factor Against Clinical and Covert Brain Infarcts: The Framingham Heart Study.Journal of the American Heart Association · 2026Article
- G-Protein-Coupled Estrogen Receptor 1 and Pregnancy Confer Protection Against Hypertension in Older Females.Circulation · 2025Article
- Pregnancy is linked to faster epigenetic aging in young women.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Reproductive factors and cardiometabolic disease among middle-aged and older women: a nationwide study from CHARLS.Frontiers in cardiovascular medicine · 2024Article
- Female Reproductive Events and Subclinical Atherosclerosis of the Brain and Carotid Arteriopathy: the Ohasama Study.Journal of atherosclerosis and thrombosis · 2023Article
- Impact of Adverse Gestational Milieu on Maternal Cardiovascular Health.Endocrinology · 2023Review
- Coronary artery restenosis and target lesion revascularisation in women by pregnancy history.Open heart · 2023Article
- Article
- Super-additive associations between parity and education level on mortality from cardiovascular disease and other causes: the Japan Collaborative Cohort Study.BMC women's health · 2022Article
- The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction.Evolution, medicine, and public health · 2022Article
- Live birth/parity number and the risk of incident hypertension among parous women during over 13 years of follow-up.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Sex Differences in Hypertrophic Cardiomyopathy: Interaction With Genetics and Environment.Current heart failure reports · 2021Review
- Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up.BMC pregnancy and childbirth · 2021Article
- Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parity has been shown to inversely associate with cardiovascular disease (CVD) mortality, but the evidence of epidemiological studies is still controversial. Therefore, we quantitatively assessed the relationship between parity and CVD mortality by summarizing the evidence from prospective studies. We searched MEDLINE (PubMed), EMBASE and ISI Web of Science databases for relevant prospective studies of parity and CVD mortality through the end of March 2015. Fixed- or random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Heterogeneity among studies was assessed using the I(2) statistics. All statistical tests were two-sided. Ten prospective studies were included with a total of 994,810 participants and 16,601 CVD events. A borderline significant inverse association was observed while comparing parity with nulliparous, with summarized RR = 0.79 (95% CI: 0.60-1.06; I(2) = 90.9%, P < 0.001). In dose-response analysis, we observed a significant nonlinear association between parity number and CVD mortality. The greatest risk reduction appeared when the parity number reached four. The findings of this meta-analysis suggests that ever parity is inversely related to CVD mortality. Furthermore, there is a statistically significant nonlinear inverse association between parity number and CVD mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.