ArticleJournal of the American Academy of Child and Adolescent Psychiatry2015
Intrinsic Amygdala Functional Connectivity in Youth With Bipolar I Disorder.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Lactate flux dysfunction in patients with bipolar disorder: preliminary insights from ultra-high field 7T MRSI during task and rest.Frontiers in neuroscience · 2025Article
- Functional connectivity of the amygdala subnuclei in various mood states of bipolar disorder.Molecular psychiatry · 2024Article
- Maternal prenatal social disadvantage and neonatal functional connectivity: Associations with psychopathology symptoms at age 12 months.Developmental psychology · 2024Article
- An investigation of the neural basis of anger attributions in irritable youth.Emotion (Washington, D.C.) · 2024Article
- Resting-state functional connectivity indicators of risk and resilience for self-harm in adolescent bipolar disorder.Psychological medicine · 2023Article
- The association of genetic variation in CACNA1C with resting-state functional connectivity in youth bipolar disorder.International journal of bipolar disorders · 2023Article
- Intrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Mood disorders disrupt the functional dynamics, not spatial organization of brain resting state networks.NeuroImage. Clinical · 2021Article
- Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders.The American journal of psychiatry · 2019Review
- Decreased anterior cingulate activation in a motor task in youths with bipolar disorder.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder.BMC psychiatry · 2018Article
- Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers.Drug and alcohol dependence · 2018Article
- The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research.Bipolar disorders · 2017Review
- Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study.Scientific reports · 2017Article
- Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct-disordered juvenile offenders.Human brain mapping · 2016Article
- Neural Correlates of Antidepressant Treatment Response in Adolescents with Major Depressive Disorder.Journal of child and adolescent psychopharmacology · 2016Article
- Goal Directed Worry Rules Are Associated with Distinct Patterns of Amygdala Functional Connectivity and Vagal Modulation during Perseverative Cognition.Frontiers in human neuroscience · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveBipolar disorder (BD) commonly begins during adolescence and may continue into adulthood. Studies in adults with BD suggest that disruptions in amygdalar neural circuitry explain the pathophysiology underlying the disorder. Importantly, however, amygdala subregion networks have not yet been examined in youth close to mania onset. The goal of this study was to compare resting state functional connectivity patterns in amygdala subregions in youth with bipolar I disorder with patterns in healthy controls.
methodCentromedial, laterobasal, and superficial amygdala subdivisions were assessed during rest and examined in relation to clinical measures of mania in youth (14-20 years old) with bipolar I disorder who experienced only a single episode of mania (BD; n = 20) and age-matched healthy comparison youth without any personal or family history of DSM-IV Axis I disorders (HC; n = 23).
resultsRelative to HC youth, youth with BD exhibited decreased connectivity between the laterobasal subdivision of the amygdala and the hippocampus and precentral gyrus, and increased connectivity between the laterobasal subdivision and the precuneus. Connectivity between the right laterobasal amygdala and right hippocampus was positively correlated with levels of anxiety in BD but not in HC youth, and connectivity between the right laterobasal amygdala and right precuneus was negatively correlated with insight about bipolar illness.
conclusionYouth with BD have abnormal amygdala resting state network connections to regions that are critical for emotional processing and self-awareness. Longitudinal studies are needed to determine whether these aberrant patterns in youth with BD can be altered with intervention and can influence the course of disorder.
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