Trial reportAmerican heart journal2015
Worsening heart failure during hospitalization for acute heart failure: Insights from the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF).
Trial report in American heart journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pharmacological interventions for heart failure in people with chronic kidney disease.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of Tolvaptan in patients with acute heart failure: a systematic review and meta-analysis.BMC cardiovascular disorders · 2017Pooled it
- Aetiology, timing and clinical predictors of early vs. late readmission following index hospitalization for acute heart failure: insights from ASCEND-HF.European journal of heart failure · 2018Trial
- Serelaxin in addition to standard therapy in acute heart failure: rationale and design of the RELAX-AHF-2 study.European journal of heart failure · 2017Trial
- A Contemporary Perspective on Acute Decompensated Heart Failure Classification: A State-of-the-art Review from an International Expert Group.Cardiac failure review · 2026Review
- Study protocol for prospect trial to elucidate the utility of echocardiography-based cardiac output in acute heart failure (PREDICT).Journal of echocardiography · 2020Observational
- Patterns of dyspnoea onset in patients with acute heart failure: clinical and prognostic implications.ESC heart failure · 2019Article
- Nine contemporary therapeutic directions in heart failure.Heart Asia · 2019Review
- Optimal hydration volume among high-risk patients with advanced congestive heart failure undergoing coronary angiography.Oncotarget · 2018Article
- In-hospital worsening heart failure: a clinically relevant endpoint?ESC heart failure · 2018Review
- Acute Heart Failure: Definition, Classification and Epidemiology.Current heart failure reports · 2017Review
- Interventional procedures and future drug therapy for hypertension.European heart journal · 2017Review
- Implications of Using Different Definitions on Outcomes in Worsening Heart Failure.Circulation. Heart failure · 2016Article
- Differences in health care use and outcomes by the timing of in-hospital worsening heart failure.American heart journal · 2015Article
- The Impact of Worsening Heart Failure in the United States.Heart failure clinics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundDespite initial in-hospital treatment of acute heart failure (HF), some patients experience worsening HF (WHF). There are limited data about the outcomes and characteristics of patients who experience in-hospital WHF. METHODS AND
resultsWe assessed the characteristics and outcomes of patients with and without WHF in the ASCEND-HF trial. Worsening HF was defined as at least 1 symptom or sign of new, persistent, or WHF requiring additional intravenous inotropic/vasodilator or mechanical therapy during index hospitalization. We assessed the relationship between WHF and 30-day mortality, 30-day mortality or HF hospitalization, and 180-day mortality. We also assessed whether there was a differential association between early (days 1-3) vs late (day ≥4) WHF and outcomes. Of 7,141 patients with acute HF, 354 (5%) experienced WHF. Patients with WHF were more often male and had a history of atrial fibrillation or diabetes, lower blood pressure, and higher creatinine. After risk adjustment, WHF was associated with increased 30-day mortality (odds ratio 13.37, 95% CI 9.85-18.14), 30-day mortality or HF rehospitalization (odds ratio 6.78, 95% CI 5.25-8.76), and 180-day mortality (hazard ratio 3.90, 95% CI 3.14-4.86) (all P values < .0001). There was no evidence of a difference in outcomes between early and late WHF (all P values for comparison ≥ .2).
conclusionsWorsening HF during index hospitalization was associated with worse 30- and 180-day outcomes. Worsening HF may represent an important patient-centered outcome in acute HF and a focus of future treatments.
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Registered trials
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