ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2015
Hypoglycorrhachia in adults with community-acquired meningitis: etiologies and prognostic significance.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Meningoencephalitis in Flea-Borne Typhus: A Report of Two Cases and a Review of CNS Complications.Pathogens (Basel, Switzerland) · 2026Review
- Clinical features and risk factors for Epstein-Barr virus-associated encephalitis: a retrospective cohort study.Virology journal · 2025Article
- Varicella-Zoster Virus Meningitis With Hypoglycorrhachia Mimicking Tuberculous Meningitis: A Case Report.Cureus · 2025Article
- Varicella-zoster virus meningitis with hypoglycorrhachia, presenting with painless occipital herpes zoster mimicking atopic dermatitis.BMJ case reports · 2025Article
- Talaromyces marneffei central nervous system infection unveiled by the novel Mp1p antigen detection assay in AIDS patient.BMC infectious diseases · 2024Article
- West Nile Disease Symptoms and Comorbidities: A Systematic Review and Analysis of Cases.Tropical medicine and infectious disease · 2022Review
- Diagnostic and Prognostic Value of Cerebrospinal Fluid Lactate and Glucose in HIV-Associated Tuberculosis Meningitis.Microbiology spectrum · 2022Article
- Stroke-like Symptoms as Presenting Signs of Varicella Zoster Meningitis in an Immunocompetent Adult.Cureus · 2022Article
- Recurrent Aseptic Meningitis Associated with Kikuchi's Disease (Histiocytic Necrotizing Lymphadenitis): A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2021Review
- The Impact of Hyponatremia on the Severity of Childhood Tuberculous Meningitis.Frontiers in neurology · 2021Article
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- AIDS-associated Talaromyces marneffei central nervous system infection in patients of southwestern China.AIDS research and therapy · 2020Article
- Chronic alcohol abuse affects the clinical course and outcome of community-acquired bacterial meningitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Varicella Zoster Meningitis with Hypoglycorrhachia on Cerebrospinal Fluid (CSF) Analysis in a Young Immunocompetent Host without a Rash.The American journal of case reports · 2019Article
- Pleocytosis is not fully responsible for low CSF glucose in meningitis.Neurology(R) neuroimmunology & neuroinflammation · 2018Article
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5 authors.
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Abstract
objectivesHypoglycorrhachia (cerebrospinal fluid (CSF) glucose <45 mg/dl) has been identified as a prognostic factor in patients with meningitis. The differential diagnosis of hypoglycorrhachia and its clinical significance was analyzed in the present study.
methodsThis was a retrospective study of 620 adult patients with community-acquired meningitis (CSF white blood cell count >5 × 10(6) cells/l and absence of a CSF shunt or recent neurosurgical procedure (<1 month)) at eight Memorial Hermann hospitals in Houston, Texas, from January 2005 to December 2010. An adverse clinical outcome was defined as a Glasgow outcome scale score of ≤ 4.
resultsOut of 620 patients with meningitis, 116 (19%) had hypoglycorrhachia. Etiologies of hypoglycorrhachia were idiopathic (n=40), bacterial (n=27), cryptococcal (n=26), viral (n=15), and tuberculous (n=4). Patients with hypoglycorrhachia were more likely to be immunosuppressed, have a history of intravenous drug use, and present with a vesicular or petechial rash, nausea or vomiting, nuchal rigidity, sinusitis/otitis, abnormal mental status, and focal neurological deficits compared to those patients without hypoglycorrhachia (p<0.05). Additionally, patients in the hypoglycorrhachia group had significantly higher rates of positive CSF and blood cultures, urgent treatable conditions, and abnormal cranial imaging (p<0.05). Furthermore, patients with hypoglycorrhachia had more adverse clinical outcomes (26/116 (22.4%) vs. 45/504 (8.9%); p<0.001).
conclusionHypoglycorrhachia has significant clinical and prognostic value in the evaluation of adult patients with community-acquired meningitis.
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