Evidence map›Paper›PMID 26298827›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2016

Time perception impairment in early-to-moderate stages of Huntington's disease is related to memory deficits.

Stefania Righi, Luca Galli, Marco Paganini, Elisabetta Bertini, Maria Pia Viggiano, Silvia Piacentini

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. The role of low-frequency rTMS in the superior parietal cortex during time estimation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Trial
  2. Article
  3. Article
  4. Disordered Decision Making: A Cognitive Framework for Apathy and Impulsivity in Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022
    Review
  5. Ramping activity in the striatum.Frontiers in computational neuroscience · 2022
    Article
  6. Methylphenidate modifies activity in the prefrontal and parietal cortex accelerating the time judgment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Stefania RighiDepartment of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Via di San Salvi 12, Pad. 26, 50100, Florence, Italy. srighi@unifi.it.
Luca GalliDepartment of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Via di San Salvi 12, Pad. 26, 50100, Florence, Italy.
Marco PaganiniII Neurological Unit, Careggi University Hospital, Florence, Italy.
Elisabetta BertiniII Neurological Unit, Careggi University Hospital, Florence, Italy.
Maria Pia ViggianoDepartment of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Via di San Salvi 12, Pad. 26, 50100, Florence, Italy.
Silvia PiacentiniDepartment of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Via di San Salvi 12, Pad. 26, 50100, Florence, Italy.
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) primarily affects striatum and prefrontal dopaminergic circuits which are fundamental neural correlates of the timekeeping mechanism. The few studies on HD mainly investigated motor timing performance in second durations. The present work explored time perception in early-to-moderate symptomatic HD patients for seconds and milliseconds with the aim to clarify which component of the scalar expectancy theory (SET) is mainly responsible for HD timing defect. Eleven HD patients were compared to 11 controls employing two separate temporal bisection tasks in second and millisecond ranges. Our results revealed the same time perception deficits for seconds and milliseconds in HD patients. Time perception impairment in early-to-moderate stages of Huntington's disease is related to memory deficits. Furthermore, both the non-systematical defect of temporal sensitivity and the main impairment of timing performance in the extreme value of the psychophysical curves suggested an HD deficit in the memory component of the SET. This result was further confirmed by the significant correlations between time perception performance and long-term memory test scores. Our findings added important preliminary data for both a deeper comprehension of HD time-keeping deficits and possible implications on neuro-rehabilitation practices.

Indexed as

Time PerceptionFemaleHumansHuntington DiseaseMaleMemory DisordersMiddle AgedNeuropsychological TestsPsychophysicsSeverity of Illness IndexEpisodic memoryHuntington’s diseaseTemporal bisection-taskTime perception

Identifiers

PMID26298827
OpenAlexW1127500754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.