ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016
Midterm follow-up after implantation of a polyurethane meniscal scaffold for segmental medial meniscus loss: maintenance of good clinical and MRI outcome.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- No differences in clinical outcome between CMI and Actifit meniscal scaffolds: a systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- Similar clinical outcomes following collagen or polyurethane meniscal scaffold implantation: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Pooled it
- Polyurethane meniscal scaffolds lead to better clinical outcomes but worse articular cartilage status and greater absolute meniscal extrusion.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Pooled it
- Meniscal tissue engineering: Bridging clinical needs and experimental innovation.Journal of orthopaedic translation · 2026Review
- Long-term clinical and MRI outcomes of a polyurethane meniscal scaffold implantation for the treatment of partial meniscal deficiency: A minimum 10-year follow-up study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Meniscal allograft transplantation and scaffolds: a narrative review.Annals of joint · 2026Review
- Meniscal fibrocartilage regeneration inspired by meniscal maturational and regenerative process.Science advances · 2023Article
- Placement of a polyurethane implant is not associated with a chondroprotective effect: comparative study with cases of isolated medial meniscectomy with at least five years of follow-up.Archives of orthopaedic and trauma surgery · 2023Article
- Polyurethane Scaffold vs Fascia Lata Autograft for Hip Labral Reconstruction: Comparison of Femoroacetabular Biomechanics.Orthopaedic journal of sports medicine · 2023Article
- Rational design of biodegradable thermoplastic polyurethanes for tissue repair.Bioactive materials · 2022Review
- Muscle strength but not balance improves after arthroscopic biodegradable polyurethane meniscus scaffold application.Musculoskeletal surgery · 2022Observational
- A review of strategies for development of tissue engineered meniscal implants.Biomaterials and biosystems · 2021Review
- Article
- Biosynthetic scaffolds for partial meniscal loss: A systematic review from animal models to clinical practice.Bioactive materials · 2021Review
- Labral reconstruction with polyurethane implant.Journal of hip preservation surgery · 2021Article
- Meniscal scaffold for the treatment of partial meniscal defect-clinical and radiological outcomes in a two-year follow-up.International orthopaedics · 2021Article
- Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies.Frontiers in cell and developmental biology · 2021Review
- Polyurethane scaffold implants for partial meniscus lesions: delayed intervention leads to an inferior outcome.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Meniscal substitution, a developing and long-awaited demand.Journal of experimental orthopaedics · 2020Review
- Ongoing MRI remodeling 3-7 years after collagen meniscus implantation in stable knees.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe preservation of meniscal structure and function after segmental meniscal loss is of crucial importance to prevent early development of osteoarthritis. Implantation of artificial meniscal implants has been reported as a feasible treatment option. The purpose of this study was to assess the clinical and magnetic resonance imaging (MRI) results 4 years after implantation of a polyurethane scaffold for chronic segmental medial meniscus deficiency following partial medial meniscectomy.
methodsEighteen patients received arthroscopic implantation of an Actifit(®) polyurethane meniscal implant (Orteq Sports Medicine, London, UK) for deficiency of the medial meniscus. Patients were followed at 6, 12, 24, and 48 months. Clinical outcome was assessed using established patient-reported outcome scores (KOOS, KSS, UCLA Activity Scale, VAS for pain). Radiological outcome was quantified by MRI scans after 6, 12, 24, and 48 months evaluating scaffold morphology, tissue integration, and status of the articular cartilage as well as signs of inflammation.
resultsMedian patient age was 32.5 years (range 17-49 years) with a median meniscal defect size of 44.5 mm (range 35-62 mm). Continuing improvement of the VAS and KSS Knee and Function Scores could be observed after 48 months compared to baseline, whereas improvement of the activity level according to UCLA continued only up to 24 months and decreased from there on. The KOOS Score showed significant improvement in all dimensions. MRI scans showed reappearance of bone bruises in two patients with scaffold extrusion. No significant changes in the articular cartilage could be perceived.
conclusionArthroscopic treatment for patients with chronic segmental meniscal loss using a polyurethane meniscal implant can achieve sustainable midterm results regarding pain reduction and knee function. LEVEL OF EVIDENCE: IV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.