ArticleMolecular neurobiology2016
LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor.
Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- ORY-1001 Delays Retinal Photoreceptor Degeneration in rd10 Mice by Inhibiting H3K4me2 Demethylation.Biology · 2026Article
- Article
- Centromere inactivation during aging can be rescued in human cells.Molecular cell · 2025Article
- Exploring Histone Modifications in Inherited Retinal Disorders.Advances in experimental medicine and biology · 2025Review
- Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells.Scientific reports · 2024Article
- Revealing the role of epigenetic and post-translational modulations of autophagy proteins in the regulation of autophagy and cancer: a therapeutic approach.Molecular biology reports · 2023Review
- Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa.Cell reports · 2023Article
- The role of epigenetic methylation/demethylation in the regulation of retinal photoreceptors.Frontiers in cell and developmental biology · 2023Review
- Deletion of histone demethylaseFrontiers in cellular neuroscience · 2023Article
- LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer.Molecular cancer · 2022Article
- Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis.Nature communications · 2022Article
- Inhibition of Epigenetic Modifiers LSD1 and HDAC1 Blocks Rod Photoreceptor Death in Mouse Models of Retinitis Pigmentosa.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Epigenetic regulation of retinal development.Epigenetics & chromatin · 2021Review
- LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development.Nature communications · 2020Article
- Native internally calibrated chromatin immunoprecipitation for quantitative studies of histone post-translational modifications.Nature protocols · 2019Article
- Histone demethylases in neuronal differentiation, plasticity, and disease.Current opinion in neurobiology · 2019Review
- Review
- Characterization of LSD1 Expression Within the Murine Eye.Investigative ophthalmology & visual science · 2019Article
- Pluripotent Stem Cells as Models of Retina Development.Molecular neurobiology · 2019Review
- DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2.Cancer communications (London, England) · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Epigenetic modifiers can work in concert with transcription factors to control the transition of cells from proliferating progenitors into quiescent terminally differentiated cells. This transition involves changes in histone methylation and one of the key regulators of this is the H3K4me2/1 histone demethylase LSD1. Here, we show that the highest expression of LSD1 occurs in postmitotic retinal cells during the peak period of rod photoreceptor differentiation. Pharmacological inhibition of LSD1 in retinal explants cultured from PN1 to PN8 had three major effects. It prevented the normal decrease in expression of genes associated with progenitor function, it blocked rod photoreceptor development, and it increased expression of genes associated with other retinal cell types. The maintained expression of progenitor genes was associated with a maintained level of H3K4me2 over the gene and its promoter. Among the genes whose expression was maintained was Hes1, a repressor known to block rod photoreceptor development. The inhibition of rod photoreceptor gene expression occurred in spite of the normal expression of transcription factors CRX and NRL, and the normal accumulation of H3K4me2 marks over the promoter and gene body. We suggest that LSD1 acts in concert with a series of nuclear receptors to modify chromatin structure and repress progenitor genes as well as to inhibit ectopic patterns of gene expression in the differentiating postmitotic retinal cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.