ReviewTrends in immunology2015
Exploiting genomics and natural genetic variation to decode macrophage enhancers.
Review in Trends in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Multi-level transcriptional control of specific macrophage responses.The EMBO journal · 2026Review
- Epigenetics of neural differentiation: Spotlight on enhancers.Frontiers in cell and developmental biology · 2022Review
- How transcription factors drive choice of the T cell fate.Nature reviews. Immunology · 2021Review
- Review
- Microglia in neurodegenerative diseases.Neural regeneration research · 2021Review
- The Cell Culture Environment Regulates the Transcription Factor MafB in BV-2 Microglia.Matters · 2021Article
- Response to Oxidative Burst-Induced Hypoxia Is Associated With Macrophage Inflammatory Profiles as Revealed by Cellular Genome-Wide Association.Frontiers in immunology · 2021Article
- Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits.American journal of human genetics · 2020Article
- Epigenetic regulation of macrophages: from homeostasis maintenance to host defense.Cellular & molecular immunology · 2020Review
- Influence of genetic polymorphism on transcriptional enhancer activity in the malaria vector Anopheles coluzzii.Scientific reports · 2019Article
- Nature and nurture of tissue-specific macrophage phenotypes.Atherosclerosis · 2019Review
- Genome-wide approaches to unravelling host-virus interactions in Dengue and Zika infections.Current opinion in virology · 2019Review
- Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection.BMC genomics · 2019Article
- Global transcriptional activity dynamics reveal functional enhancer RNAs.Genome research · 2018Article
- Development and maintenance of the brain's immune toolkit: Microglia and non-parenchymal brain macrophages.Developmental neurobiology · 2018Review
- Genome-wide profiling of transcribed enhancers during macrophage activation.Epigenetics & chromatin · 2017Article
- Article
- Article
- Epigenetic Regulation of Monocyte and Macrophage Function.Antioxidants & redox signaling · 2016Review
- A polarizing question: do M1 and M2 microglia exist?Nature neuroscience · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The mammalian genome contains on the order of a million enhancer-like regions that are required to establish the identities and functions of specific cell types. Here, we review recent studies in immune cells that have provided insight into the mechanisms that selectively activate certain enhancers in response to cell lineage and environmental signals. We describe a working model wherein distinct classes of transcription factors define the repertoire of active enhancers in macrophages through collaborative and hierarchical interactions, and discuss important challenges to this model, specifically providing examples from T cells. We conclude by discussing the use of natural genetic variation as a powerful approach for decoding transcription factor combinations that play dominant roles in establishing the enhancer landscapes, and the potential that these insights have for advancing our understanding of the molecular causes of human disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.