ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Regulatory T Cells, Frailty, and Immune Activation in Men Who Have Sex With Men in the Multicenter AIDS Cohort Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV.Journal of clinical immunology · 2025Article
- Characterization of data-driven geriatric syndrome clusters in older people with HIV: a Mexican multicenter cross-sectional study.Lancet regional health. Americas · 2023Article
- Pressing Questions and Challenges in the HIV-1 and SARS-CoV-2 Syndemic.AIDS research and human retroviruses · 2021Article
- Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda.Journal of neurovirology · 2021Article
- Frailty in People Living with HIV.Current HIV/AIDS reports · 2020Review
- Article
- The dynamic association between Frailty, CD4 and CD4/CD8 ratio in people aging with HIV.PloS one · 2019Article
- Can Biomarkers Advance HIV Research and Care in the Antiretroviral Therapy Era?The Journal of infectious diseases · 2018Review
- Geriatric syndromes: new frontiers in HIV and sarcopenia.AIDS (London, England) · 2017Review
- Frailty and Circulating Markers of Inflammation in HIV+ and HIV- Men in the Multicenter AIDS Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Predictors of transitions in frailty severity and mortality among people aging with HIV.PloS one · 2017Article
- The effect of cellular isolation and cryopreservation on the expression of markers identifying subsets of regulatory T cells.Journal of immunological methods · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBoth HIV infection and frailty have been associated with chronic immune activation. One possible explanation for this chronic immune activation could be low levels of CD4(+) T regulatory cells (Tregs), which suppress immune responses.
methodsHIV-uninfected (HIV-) and HIV-infected (HIV+) men in the Multicenter AIDS Cohort Study (MACS) were classified as frail (or nonfrail) if they expressed (or did not express) the Fried frailty phenotype at two consecutive study visits. Percentages and absolute numbers of total Tregs, and percentages of different subsets of Tregs and of activated T cells were measured by flow cytometry. The function of Tregs was measured by suppression of T-cell proliferation.
resultsPercentages of Tregs were higher, rather than lower, in frail men than in nonfrail men, and this difference was significant for HIV- men. Percentages of subsets of Tregs did not differ significantly by frailty status. Among HIV+ men, the suppressive function of Tregs was similar between frail and nonfrail men. Percentages of Tregs and activated T cells were negatively correlated in nonfrail men (HIV- and HIV+) and in frail HIV- men, but this correlation was strongly positive in frail HIV+ men.
conclusionThese data suggest that: (a) Tregs were not deficient in frail men; and (b) the immunological pathophysiology of frailty may differ by HIV status.
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