ArticleG3 (Bethesda, Md.)2015
Similar Efficacies of Selection Shape Mitochondrial and Nuclear Genes in Both Drosophila melanogaster and Homo sapiens.
Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Sensitivity of genome-wide tests for mitonuclear genetic incompatibilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Codon usage bias and selective constraints in Gentianales mitogenomes.BMC genomics · 2026Article
- Phylogenomic Analysis Reveals Evolutionary Relationships of Tropical Drosophilidae: FromEcology and evolution · 2025Article
- Review
- A chromosome-scale genome assembly and evaluation of mtDNA variation in the willow leaf beetle Chrysomela aeneicollis.G3 (Bethesda, Md.) · 2023Article
- Mitochondrial effects on fertility and longevity inProceedings. Biological sciences · 2022Article
- Patterns of Population Structure and Introgression Among Recently Differentiated Drosophila melanogaster Populations.Molecular biology and evolution · 2022Article
- Genomic Signatures of Mitonuclear Coevolution in Mammals.Molecular biology and evolution · 2022Article
- Diversification, Introgression, and Rampant Cytonuclear Discordance in Rocky Mountains Chipmunks (Sciuridae: Tamias).Systematic biology · 2021Article
- Mother's curse is pervasive across a large mitonuclearEvolution letters · 2021Article
- Mitonuclear Coevolution, but not Nuclear Compensation, Drives Evolution of OXPHOS Complexes in Bivalves.Molecular biology and evolution · 2021Article
- Gene flow as a simple cause for an excess of high-frequency-derived alleles.Evolutionary applications · 2020Article
- High mitochondrial mutation rates inBiology letters · 2020Article
- Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses.Molecular biology and evolution · 2020Article
- Cytonuclear Genetic Incompatibilities in Plant Speciation.Plants (Basel, Switzerland) · 2020Review
- Assessing the fitness consequences of mitonuclear interactions in natural populations.Biological reviews of the Cambridge Philosophical Society · 2019Article
- Population Genetics of Paramecium Mitochondrial Genomes: Recombination, Mutation Spectrum, and Efficacy of Selection.Genome biology and evolution · 2019Article
- Sex and Mitonuclear Adaptation in ExperimentalGenetics · 2019Article
- Maternal age effects on fecundity and offspring egg-to-adult viability are not affected by mitochondrial haplotype.Ecology and evolution · 2018Article
- Cytonuclear integration and co-evolution.Nature reviews. Genetics · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Deleterious mutations contribute to polymorphism even when selection effectively prevents their fixation. The efficacy of selection in removing deleterious mitochondrial mutations from populations depends on the effective population size (Ne) of the mitochondrial DNA and the degree to which a lack of recombination magnifies the effects of linked selection. Using complete mitochondrial genomes from Drosophila melanogaster and nuclear data available from the same samples, we reexamine the hypothesis that nonrecombining animal mitochondrial DNA harbor an excess of deleterious polymorphisms relative to the nuclear genome. We find no evidence of recombination in the mitochondrial genome, and the much-reduced level of mitochondrial synonymous polymorphism relative to nuclear genes is consistent with a reduction in Ne. Nevertheless, we find that the neutrality index, a measure of the excess of nonsynonymous polymorphism relative to the neutral expectation, is only weakly significantly different between mitochondrial and nuclear loci. This difference is likely the result of the larger proportion of beneficial mutations in X-linked relative to autosomal loci, and we find little to no difference between mitochondrial and autosomal neutrality indices. Reanalysis of published data from Homo sapiens reveals a similar lack of a difference between the two genomes, although previous studies have suggested a strong difference in both species. Thus, despite a smaller Ne, mitochondrial loci of both flies and humans appear to experience similar efficacies of purifying selection as do loci in the recombining nuclear genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.