ArticleBMC developmental biology2015
The growth pattern of the human intestine and its mesentery.
Article in BMC developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Adult Presentations of Congenital Midgut Malrotation: A Systematic Review.World journal of surgery · 2020Pooled it
- Article
- Common hepatic artery branching from the superior mesenteric artery with a common trunk of the inferior pancreaticoduodenal artery and first jejunal artery.Anatomical science international · 2026Article
- The junction between the midgut and hindgut co-localizes with the rectosigmoid junction.Journal of anatomy · 2026Article
- Superior Mesenteric Artery during Intestinal Loop Formation and Its Positional Changes from the Extracoelom to the Abdominal Cavity.Cells, tissues, organs · 2026Article
- The Development of the Human Female Reproductive Tract: Part 2-Vagina.Clinical anatomy (New York, N.Y.) · 2026Article
- Unveiling midgut volvulus: the critical role of ultrasound.Przeglad gastroenterologiczny · 2026Article
- Midgut protrusion, rotation, and retraction induced by temporal alteration in differential growth.Biomechanics and modeling in mechanobiology · 2025Article
- Article
- The development of the external genitals in female human embryos and foetuses. Part 1: Perineal thick skin, clitoris and labia.Journal of anatomy · 2025Article
- A rare case of midgut malrotation leading to small bowel obstruction in an adult: a case report.Frontiers in surgery · 2025Article
- Dynamic responses of a vibro-impact capsule robot self-propelling in the large intestine via multibody dynamics.Multibody system dynamics · 2025Article
- Article
- The mesenteric entry site as a potential weak point in gastrointestinal anastomoses - findings from an ex-vivo biomechanical analysis.Langenbeck's archives of surgery · 2024Article
- An Unusual Coexistence: Right-Sided Colon Cancer and Intestinal Malrotation in an Adult.Cureus · 2024Article
- Developmental regulation of cellular metabolism is required for intestinal elongation and rotation.Development (Cambridge, England) · 2024Article
- Thoracoabdominal duplication accompanied by intestinal malrotation: a case report and literature review of a rare congenital anomaly in an infant.Annals of medicine and surgery (2012) · 2024Article
- Diagnostic accuracy of upper gastrointestinal series in children with suspected intestinal malrotation.Updates in surgery · 2024Article
- Adult Midgut Malrotation With Chronic Volvulus With Superior Mesenteric Artery (SMA) Thrombosis: A Recherche.Cureus · 2023Article
- The concept of developmental anatomy: the greater omentum should be resected in right-sided colon cancer?BMC surgery · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visualization techniques.
resultsWe distinguished 3 generations of midgut loops. The topography of primary and secondary loops was constant, but that of tertiary loops not. The orientation of the primary loop changed from sagittal to transverse due to the descent of ventral structures in a body with a still helical body axis. The 1st secondary loop (duodenum, proximal jejunum) developed intraabdominally towards a left-sided position. The 2nd secondary loop (distal jejunum) assumed a left-sided position inside the hernia before returning, while the 3rd and 4th secondary loops retained near-midline positions. Intestinal return into the abdomen resembled a backward sliding movement. Only after return, the 4th secondary loop (distal ileum, cecum) rapidly "slid" into the right lower abdomen. The seemingly random position of the tertiary small-intestinal loops may have a biomechanical origin.
conclusionsThe interpretation of "intestinal rotation" as a mechanistic rather than a descriptive concept underlies much of the confusion accompanying the physiological herniation. We argue, instead, that the concept of "en-bloc rotation" of the developing midgut is a fallacy of schematic drawings. Primary, secondary and tertiary loops arise in a hierarchical fashion. The predictable position and growth of secondary loops is pre-patterned and determines adult intestinal topography. We hypothesize based on published accounts that malrotations result from stunted development of secondary loops.
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