ArticleBiological research2015
Integrated analyses of copy number variations and gene differential expression in lung squamous-cell carcinoma.
Article in Biological research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Association of circulating metabolic biomarkers with risk of lung cancer: a population-based prospective cohort study.BMC medicine · 2025Article
- A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis.Scientific reports · 2025Article
- Unveiling the Enigmatic Role of SLC35F3 in Lung Adenocarcinoma.The clinical respiratory journal · 2024Article
- Genome-wide investigation to assess copy number variants in the Italian local chicken population.Journal of animal science and biotechnology · 2024Article
- Identifying General Tumor and Specific Lung Cancer Biomarkers by Transcriptomic Analysis.Biology · 2022Article
- Use of four genes in exosomes as biomarkers for the identification of lung adenocarcinoma and lung squamous cell carcinoma.Oncology letters · 2021Article
- Copy number variation is highly correlated with differential gene expression: a pan-cancer study.BMC medical genetics · 2019Article
- [Identification of differentially expressed genes between lung adenocarcinoma and squamous cell carcinoma using transcriber signature analysis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Studying the mechanism of PLAGL2 overexpression and its carcinogenic characteristics based on 3'-untranslated region in colorectal cancer.International journal of oncology · 2018Article
- Tumor suppressive role of miR-569 in lung cancer.Oncology letters · 2018Article
- Identification of novel prognosis-related genes associated with cancer using integrative network analysis.Scientific reports · 2018Article
- Association Analysis of Somatic Copy Number Alteration Burden With Breast Cancer Survival.Frontiers in genetics · 2018Article
- Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis.Oncotarget · 2017Article
- Article
- Growth, progression and chromosome instability of Neuroblastoma: a new scenario of tumorigenesis?BMC cancer · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and copy number variation (CNV).
resultsA higher burden of the CNVs was found in 10-50 kb length. The 16 CNV-driven genes mainly located in chr 1 and chr 3 were enriched in immune response [e.g. complement factor H (CFH) and Fc fragment of IgG, low affinity IIIa, receptor (FCGR3A)], starch and sucrose metabolism [e.g. amylase alpha 2A (AMY2A)]. Furthermore, 38 TFs were screened for the 9 CNV-driven genes and then the regulatory network was constructed, in which the GATA-binding factor 1, 2, and 3 (GATA1, GATA2, GATA3) jointly regulated the expression of TP63.
conclusionsThe above CNV-driven genes might be potential contributors to the development of lung SCC.
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