ArticleBMJ open2015
Trends and risk factors for HIV, HCV and syphilis seroconversion among drug users in a methadone maintenance treatment programme in China: a 7-year retrospective cohort study.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Needle syringe programmes and opioid substitution therapy for preventing hepatitis C transmission in people who inject drugs.The Cochrane database of systematic reviews · 2017Pooled it
- Family Related Factors and Concurrent Heroin Use in Methadone Maintenance Treatment in China.Substance use & misuse · 2018Trial
- Concurrent Heroin Use and Correlates among Methadone Maintenance Treatment Clients: A 12-Month Follow-up Study in Guangdong Province, China.International journal of environmental research and public health · 2016Trial
- The correlation between drug abuse belief, refusal of self-efficacy and drug craving of patients in the treatment of methadone replacement treatment.Frontiers in psychology · 2026Article
- Machine learning model for predicting hepatitis C seroconversion in methadone maintenance patients in China.BMJ public health · 2025Article
- Modeling the Impacts of Prevention and Treatment Interventions on Hepatitis C Among People Who Inject Drugs in China.Infectious diseases and therapy · 2023Article
- Methods and indicators to validate country reductions in incidence of hepatitis C virus infection to elimination levels set by WHO.The lancet. Gastroenterology & hepatology · 2022Review
- Spatio-temporal variation on syphilis from 2005 to 2018 in Zhejiang Province, China.Frontiers in public health · 2022Article
- Linking criminal justice-involved individuals to HIV, Hepatitis C, and opioid use disorder prevention and treatment services upon release to the community: Progress, gaps, and future directions.The International journal on drug policy · 2021Article
- Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China.Frontiers in public health · 2021Article
- Sociodemographic Factors Associated With HIV/HCV High-Risk Behaviors Among People Who Use Drugs on Methadone Maintenance Treatment: A 10-Year Observational Study.Frontiers in psychiatry · 2021Article
- Interventions to improve the HIV continuum of care in China.Current HIV/AIDS reports · 2019Review
- Hepatitis C Virus Treatment Status and Barriers among Patients in Methadone Maintenance Treatment Clinics in Guangdong Province, China: A Cross-Sectional, Observational Study.International journal of environmental research and public health · 2019Observational
- The Decade-Long Chinese Methadone Maintenance Therapy Yields Large Population and Economic Benefits for Drug Users in Reducing Harm, HIV and HCV Disease Burden.Frontiers in public health · 2019Article
- Factors associated with concurrent heroin use among patients on methadone maintenance treatment in Vietnam: A 24-month retrospective analysis of a nationally representative sample.The International journal on drug policy · 2018Article
- Expanding syphilis testing: a scoping review of syphilis testing interventions among key populations.Expert review of anti-infective therapy · 2018Article
- An Update on the Global Epidemiology of Syphilis.Current epidemiology reports · 2018Article
- Strategies to control HIV and HCV in methadone maintenance treatment in Guangdong Province, China: a system dynamic modeling study.Substance abuse treatment, prevention, and policy · 2018Article
- Loneliness and its impact on quality of life in Chinese heroin-dependent patients receiving methadone maintenance treatment.Oncotarget · 2017Article
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3 authors.
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Abstract
objectiveThis study explores the trends and associated factors of HIV, hepatitis C virus (HCV) and syphilis seroconversion among Chinese methadone maintenance treatment (MMT) clients over a follow-up period of up to 7 years.
designDrug users from 14 MMT clinics in Guangdong Province were recruited during 2006-2014. Participants were seronegative with at least one HIV, HCV or syphilis infection at baseline and had completed at least one follow-up test during the study period. We estimated HIV, HCV and syphilis seroconversion rates in follow-up years and identified the underlying predictors using a multivariate Cox regression model.
resultsAmong 9240 participants, the overall HIV seroconversion rate was 0.20 (0.13 to 0.28)/100 person-years (pys), 20.54 (18.62 to 22.46)/100 pys for HCV and 0.77 (0.62 to 0.93)/100 pys for syphilis, over the study period. HIV seroconversion rate showed a moderate but non-significant annual decline of 13.34% (-42.48% to 30.56%) (χ(2) trend test; p=0.369), whereas the decline of HCV seroconversion was 16.12% (5.53% to 25.52%) per annum (p<0.001). Syphilis seroconversion rate remained stable (p=0.540). Urine results positive for opioid predicted HIV seroconversion (≥ 60% vs <60%; HR=3.40, 1.07 to 10.85), being unmarried (HR=1.59, 1.15 to 2.20), injection drug use in the past 30 days (HR=2.17, 1.42 to 3.32), having sexual intercourse in the past 3 months (HR=1.74, 1.22 to 2.47) and higher daily dosage of methadone (≥ 60 mL vs <60 mL; HR=1.40, 1.01 to 1.94) predicted HCV seroconversion. Being female (HR=3.56, 2.25 to 5.64) and infected with HCV at baseline (HR=2.40, 1.38 to 8.36) were associated with subsequent syphilis seroconversion.
conclusionsMMT in China has demonstrated moderate-to-good effectiveness in reducing HIV and HCV incidence but not syphilis infection among participating drug users.
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