ArticleBMJ open2015
Association between lymphocyte-to-monocyte ratio (LMR) and the mortality of HBV-related liver cirrhosis: a retrospective cohort study.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- A New Nomogram for Mortality Prediction Within 5 Years in Portal Vein Thrombosis due to Hepatitis B-Related Cirrhosis.Journal of viral hepatitis · 2026Article
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- The diagnostic value of decreased levels of inflammatory markers for the state of hepatitis C virus (HCV) infection.PloS one · 2025Article
- Application Value of Novel Inflammatory Indicators in Response to Ursodeoxycholic Acid Therapy in Patients with Primary Biliary Cholangitis.International journal of general medicine · 2025Article
- Relationship between platelet-to-lymphocyte ratio and early rebleeding after endoscopic variceal ligation: a bicenter retrospective study.Annals of medicine · 2024Article
- Hospital Mortality in Acute Decompensation of Alcoholic Liver Cirrhosis: Can Novel Survival Markers Outperform Traditional Ones?Journal of clinical medicine · 2024Article
- Effect of lymphocyte-to-monocyte ratio on survival in septic patients: an observational cohort study.Archives of medical science : AMS · 2024Article
- Article
- Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation.Journal of clinical medicine · 2023Article
- Psychometric tests, critical flicker frequency, and inflammatory indicators in covert hepatic encephalopathy diagnosis.Hepatology forum · 2023Article
- Platelet-to-White Blood Cell Ratio Is Associated with Adverse Outcomes in Cirrhotic Patients with Acute Deterioration.Journal of clinical medicine · 2022Article
- Non-Invasive Prediction Models for Esophageal Varices and Red Signs in Patients With Hepatitis B Virus-Related Liver Cirrhosis.Frontiers in molecular biosciences · 2022Article
- Article
- Influence of chronic hepatitis C infection on the monocyte-to-platelet ratio: data analysis from the National Health and Nutrition Examination Survey (2009-2016).BMC public health · 2021Article
- Prognostic value of neutrophil-to-lymphocyte ratio in cirrhotic patients with acute-on-chronic liver failure.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Observational
- Evaluation of the neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and red cell distribution width for the prediction of prognosis of patients with hepatitis B virus-related decompensated cirrhosis.Journal of clinical laboratory analysis · 2020Article
- Expression and significance of urinary microRNA in patients with chronic hepatitis B.Medicine · 2019Article
- Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques.Scientific reports · 2019Article
- Assessing the outcome of patients with liver cirrhosis during hospital stay: A comparison of lymphocyte/monocyte ratio with MELD and Child-Pugh scores.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma.Oncology letters · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInfection with hepatitis B virus (HBV) remains a major cause of liver cirrhosis (LC) in China. Recent reports suggest that the lymphocyte-to-monocyte ratio (LMR) is a potential biomarker for predicting clinical outcomes. In our study, we investigated if LMR can be used as a prognostic marker of mortality in patients with HBV-related LC.
designA retrospective cohort study.
settingHBV-infected patients with LC and patients with chronic hepatitis B infection (CHB) from the Department of Infectious Disease were enrolled and 240 healthy individuals were recruited from the healthcare centre at the First Affiliated Hospital of Zhejiang University.
participants479 HBV-infected patients with LC, 134 patients with CHB and 240 healthy individuals were enrolled. PRIMARY AND SECONDARY OUTCOME MEASURES: The receiver operating characteristic (ROC) curve and multivariable logistic regression analysis after adjusting for total protein, albumin, total bilirubin and the model for end-stage liver disease (MELD) score were used to evaluate the power of LMR for predicting 1 year mortality in patients with LC.
resultsThe LMR was statistically lower in patients with LC. The MELD score and mortality were statistically higher in patients with LC compared with the CHB and control groups. The area under the ROC curve, cut-off values, sensitivity and specificity of LMR for predicting mortality LC in the training cohort were 0.817 (95% CI 0.746 to 0.888; p<0.001), 2.10, 82.6 and 78.8%, and these data were confirmed in the validation cohort. The multivariate logistic regression analysis showed that LMR was an independent predictive factor of mortality in LC (OR 2.370, 95% CI (1.070 to 5.249); p=0.033).
conclusionsOur results strongly suggest that low LMR can be considered as an independent biomarker for predicting mortality in patients with LC.
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