Evidence map›Paper›PMID 26297325›Full record

Trial reportEuropean journal of applied physiology2016

Effects of pre-exercise alkalosis on the decrease in VO2 at the end of all-out exercise.

Claire Thomas, Rémi Delfour-Peyrethon, David J Bishop, Stéphane Perrey, Pierre-Marie Leprêtre, Sylvain Dorel, Christine Hanon

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Claire ThomasFrench National Institute of Sports (INSEP), 11 Tremblay Avenue, 75012, Paris, France. claire.thomas@univ-evry.fr.
Rémi Delfour-PeyrethonFrench National Institute of Sports (INSEP), 11 Tremblay Avenue, 75012, Paris, France.
David J BishopInstitute of Sport, Exercise and Active Living (ISEAL), College of Sport and Exercise Science, Victoria University, Melbourne, Australia.
Stéphane PerreyEuroMov: Movement to Health, University of Montpellier, Montpellier, France.
Pierre-Marie LeprêtreLaboratory "Adaptations physiologiques à l'exercice et réadaptation à l'effort" (EA-3300), University of Picardie Jules Verne, UFR-STAPS, 80025, Amiens Cedex, France.
Sylvain DorelLaboratory "Motricité, Interactions, Performance" (EA 4334), University of Nantes, 44000, Nantes, France.
Christine HanonFrench National Institute of Sports (INSEP), 11 Tremblay Avenue, 75012, Paris, France.
Institut National du Sport, de l'Expertise et de la Performance · FRNantes Université · FRUniversité de Montpellier · FRUniversité de Picardie Jules Verne · FRVictoria University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study determined the effects of pre-exercise sodium bicarbonate ingestion (ALK) on changes in oxygen uptake (VO2) at the end of a supramaximal exercise test (SXT).

methodsEleven well-trained cyclists completed a 70-s all-out cycling effort, in double-blind trials, after oral ingestion of either 0.3 g kg(-1) of sodium bicarbonate (NaHCO3) or 0.2 g kg(-1) body mass of calcium carbonate (PLA). Blood samples were taken to assess changes in acid-base balance before the start of the supramaximal exercise, and 0, 5 and 8 min after the exercise; ventilatory parameters were also measured at rest and during the SXT.

resultsAt the end of the PLA trial, which induced mild acidosis (blood pH = 7.20), subjects presented a significant decrease in VO2 (P < 0.05), which was related to the amplitude of the decrease in minute ventilation (VE) during the SXT (r = 0.70, P < 0.01, n = 11). Pre-exercise metabolic alkalosis significantly prevented the exercise-induced decrease in VO2 in eleven well-trained participants (PLA:12.5 ± 2.1 % and ALK: 4.9 ± 0.9 %, P < 0.05) and the decrease in mean power output was significantly less pronounced in ALK (P < 0.05). Changes in the VO2 decrease between PLA and ALK trials were positively related to changes in the VE decrease (r = 0.74, P < 0.001), but not to changes in power output (P > 0.05).

conclusionsPre-exercise alkalosis counteracted the VO2 decrease related to mild acidosis, potentially as a result of changes in VE and in muscle acid-base status during the all-out supramaximal exercise.

Indexed as

AdultAlkalosisDouble-Blind MethodExerciseExercise TestFemaleHumansHydrogen-Ion ConcentrationMaleOxygen ConsumptionPhysical ExertionSodium BicarbonateTime FactorsYoung AdultSodium BicarbonateAcid–base statusFatigueHigh-intensity exerciseMinute ventilationOxygen uptakeSodium bicarbonate

Identifiers

PMID26297325
OpenAlexW1123660276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.