ArticleClinical oral investigations2016
Investigation of the oral status and microorganisms in children with phenylketonuria and type 1 diabetes.
Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Early childhood caries and type 1 diabetes mellitus - Evidence on primary teeth and oral health: A systematic review.Biomolecules & biomedicine · 2026Pooled it
- Poor glycemic control impairs oral health in children with type 1 diabetes mellitus - a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Oral health and salivary inflammatory markers in children and adolescents with type 1 diabetes: A cross-sectional study.Journal of endocrinological investigation · 2026Article
- Comparative evaluation of oral microbiologic profile in children with Type 1 Diabetes Mellitus versus healthy controls and its relation to oral health status.BMC oral health · 2025Article
- Phenylalanine-Free Infant Formula in Patients with Phenylketonuria: A Retrospective Study.Nutrients · 2024Article
- Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus-A Comprehensive Review of Clinical Studies.International journal of molecular sciences · 2024Review
- The Impact ofDiagnostics (Basel, Switzerland) · 2024Article
- Evaluation of Decayed, Missing due to Caries, and Filled Teeth Index in Children with Phenylketonuria in Comparison to Normal Population.Turkish archives of pediatrics · 2023Article
- Oral Microbiome Traits of Type 1 Diabetes and Phenylketonuria Patients in Latvia.Microorganisms · 2023Article
- Dietary and metabolic effects on the oral status of patients with phenylketonuria: a nation-based cross-sectional study.Clinical oral investigations · 2023Article
- Dental Status and Periodontal Health of Patients with Phenylketonuria in Latvia.Acta stomatologica Croatica · 2022Article
- Evidence and possible mechanisms of probiotics in the management of type 1 diabetes mellitus.Journal of diabetes and metabolic disorders · 2022Review
- Associations between dental caries and systemic diseases: a scoping review.BMC oral health · 2021Article
- Dental caries and bacterial load in saliva and dental biofilm of type 1 diabetics on continuous subcutaneous insulin infusion.Journal of applied oral science : revista FOB · 2018Article
- Evaluation of the difference in caries experience in diabetic and non-diabetic children-A case control study.PloS one · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate the oral parameters that influence the caries risk and risk of developing periodontal disease in children with phenylketonuria (PKU) and type 1 diabetes compared to healthy children. MATERIAL AND
methodsTwo hundred and thirty-eight children between the ages of 3 and 18 years were recruited in the PKU, diabetes and healthy group. The decayed, missing and filled surfaces (dmfs/DMFS) index, papillary bleeding index (PBI) and the Silness & Löe Index were assessed. Quantitative real-time polymerase chain reaction (PCR) was used for the detection of Streptococcus mutans (Sm), Lactobacillus casei (Lca), Lactobacillus species (Lac), Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg) and Tannerella forsythensis (Tf).
resultsA statistically significant difference in the dmfs index value was found between the three groups. The mean dmfs index value for the PKU children (4.18) was found to be relatively high. Comparing the three groups, diabetics showed statistically significant higher values for the Silness and Löe Index. Comparing the diabetics to just the healthy children, the diabetics revealed a small statistically significant difference in the PBI score. A statistically significant difference was found between Lac, Lca and Pg in the three groups. Counts of Lac were the lowest in the PKU children. The diabetics showed the highest counts of Lca but lowest for Pg.
conclusionsComparing the three groups, children with PKU revealed a higher caries experience in their primary dentition. While the diabetic children showed a lower one in their primary dentition, they were found to possess a slightly higher risk of developing periodontal disease. CLINICAL RELEVANCE: It is proposed that both groups of child patients be encouraged to seek early dental advice and be incorporated in a meticulous prevention programme.
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