ArticleJournal of ophthalmic inflammation and infection2015
Clinical and laboratory characteristics of ocular syphilis: a new face in the era of HIV co-infection.
Article in Journal of ophthalmic inflammation and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Prognostic effect of HIV on visual acuity in ocular syphilis: a systematic review.Eye (London, England) · 2023Pooled it
- Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Pooled it
- Vascularized Iris Mass as Sentinel Manifestation of Syphilis in Patient with HIV Infection, Spain, 2025.Emerging infectious diseases · 2026Article
- Cytomegalovirus Retinitis in Newly Diagnosed Advanced HIV Infection: A Three-Case Series Emphasizing Multidisciplinary Infection Screening.Infectious disease reports · 2026Article
- Syphilitic Uveitis in HIV-Positive and -Negative Patients: A Multicenter Cohort Study.Turkish journal of ophthalmology · 2026Article
- Bilateral Panuveitis and Placoid Retinitis in Ocular Syphilis Complicated by Subsequent Retinal Detachment.Journal of vitreoretinal diseases · 2026Article
- Ocular Syphilis in Individuals with and Without HIV: A Single-Center University Hospital Experience.Pathogens (Basel, Switzerland) · 2026Article
- Clinical manifestations and treatment prognosis of patients with co-infection of ocular syphilis and HIV.BMC ophthalmology · 2025Article
- Diagnosis and treatment of syphilitic uveitis: Taiwan experts consensus.Journal of the Chinese Medical Association : JCMA · 2024Article
- Could ceftriaxone be a viable alternative to penicillin for the treatment of ocular syphilis?Antimicrobial agents and chemotherapy · 2024Article
- Cerebrospinal Fluid Biomarkers of Symptomatic Neurosyphilis in People With HIV Compared with Uninfected Individuals.Journal of neurovirology · 2024Article
- Retinitis Pigmentosa Masquerades: Case Series and Review of the Literature.Journal of clinical medicine · 2023Article
- Syphilitic uveitis in HIV-positive patients: report of a case series, treatment outcomes, and comprehensive review of the literature.International journal of ophthalmology · 2023Article
- Acute Syphilitic Posterior Placoid Chorioretinitis With Subfoveal Choroidal Neovascularization Managed With Anti-VEGF Therapy.Journal of vitreoretinal diseases · 2022Article
- Pyramidal Inflammatory Deposits of the Retinal Pigment Epithelium and Outer Retina in Ocular Syphilis.Ophthalmology. Retina · 2022Article
- Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.Indian journal of ophthalmology · 2020Review
- Ocular syphilis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome in the era of highly active antiretroviral therapy.Indian journal of ophthalmology · 2020Article
- The importance of proper and prompt treatment of ocular syphilis: a lesson from permanent vision loss in 52 eyes.Journal of the European Academy of Dermatology and Venereology : JEADV · 2020Article
- Syphilis Laboratory Guidelines: Performance Characteristics of Nontreponemal Antibody Tests.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging.Journal of clinical medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOcular syphilis is reemerging as an important cause of uveitis in the new era of common co-infection with HIV. This study will reveal the clinical and laboratory characteristics in the group of individuals co-infected with ocular syphilis and HIV compared with HIV-negative individuals. In this retrospective observational case series, medical records of patients diagnosed with ocular syphilis with serologic support from 2008 to 2014 were reviewed. Ocular and systemic manifestation and laboratory profiles were reviewed.
resultsTwenty-nine eyes of 16 consecutive patients (10 HIV-positive and 6 HIV-negative) were included. All patients were males, and mean age of onset for ocular syphilis was 43 (mean 42.65 ± 13.13). In both HIV-positive and HIV-negative groups, ocular manifestations of syphilis were variable including anterior uveitis (4 eyes), posterior uveitis (8 eyes), panuveitis (13 eyes), and isolated papillitis (4 eyes). In HIV-positive patients, panuveitis was the most common feature (12/18 eyes, 67 %) and serum rapid plasma reagin (RPR) titers were significantly higher (range 1:64-1:16,348; mean 1:768; p = 0.018) than in HIV-negative patients. Upon the diagnosis of ocular syphilis in HIV-positive patients, HIV-1 viral load was high (median 206,887 copies/ml) and CD4 cell count ranged from 127 to 535 cells/ml (mean 237 ± 142; median 137). Regardless of HIV status, cerebrospinal fluid (CSF) exam was frequently abnormal: positive CSF fluorescent treponemal antibody absorption (FTA-ABS) or Venereal Disease Research Laboratory (VDRL) test results in seven patients or either elevated CSF WBC count or elevated CSF protein in six patients.
conclusionsOur results reveal that the patients with ocular syphilis with high serum RPR titers may have concomitant HIV infection requiring further testing for HIV status and ocular syphilis is likely associated with the central nervous system involvement and therefore needs to be managed according to the treatment recommendations for neurosyphilis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.