ArticleThe Plant cell2015
The Axial Element Protein DESYNAPTIC2 Mediates Meiotic Double-Strand Break Formation and Synaptonemal Complex Assembly in Maize.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- The plant early recombinosome: a high security complex to break DNA during meiosis.Plant reproduction · 2024Review
- TurboID-based proteomic profiling of meiotic chromosome axes in Arabidopsis thaliana.Nature plants · 2023Article
- Meiotic chromosome organization and its role in recombination and cancer.Current topics in developmental biology · 2023Review
- Crossover interference mechanism: New lessons from plants.Frontiers in cell and developmental biology · 2023Review
- Isolation of Meiocytes and Cytological Analyses of Male Meiotic Chromosomes in Soybean, Lettuce, and Maize.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Meiotic chromosome axis remodelling is critical for meiotic recombination in Brassica rapa.Journal of experimental botany · 2021Article
- The Formation of Bivalents and the Control of Plant Meiotic Recombination.Frontiers in plant science · 2021Review
- Rewiring Meiosis for Crop Improvement.Frontiers in plant science · 2021Review
- State changes of the HORMA protein ASY1 are mediated by an interplay between its closure motif and PCH2.Nucleic acids research · 2020Article
- Derived alleles of two axis proteins affect meiotic traits in autotetraploidProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Dynamic localization of SPO11-1 and conformational changes of meiotic axial elements during recombination initiation of maize meiosis.PLoS genetics · 2020Article
- Advances Towards How Meiotic Recombination Is Initiated: A Comparative View and Perspectives for Plant Meiosis Research.International journal of molecular sciences · 2019Review
- Ultrastructure and Dynamics of Synaptonemal Complex Components During Meiotic Pairing and Synapsis of Standard (A) and Accessory (B) Rye Chromosomes.Frontiers in plant science · 2019Article
- The OsRR24/LEPTO1 Type-B Response Regulator is Essential for the Organization of Leptotene Chromosomes in Rice Meiosis.The Plant cell · 2018Article
- Identification of ASYNAPTIC4, a Component of the Meiotic Chromosome Axis.Plant physiology · 2018Article
- Article
- Tackling Plant Meiosis: From Model Research to Crop Improvement.Frontiers in plant science · 2018Review
- Bivalent Formation 1, a plant-conserved gene, encodes an OmpH/coiled-coil motif-containing protein required for meiotic recombination in rice.Journal of experimental botany · 2017Article
- Understanding and Manipulating Meiotic Recombination in Plants.Plant physiology · 2017Review
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
During meiosis, homologous chromosomes pair and recombine via repair of programmed DNA double-strand breaks (DSBs). DSBs are formed in the context of chromatin loops, which are anchored to the proteinaceous axial element (AE). The AE later serves as a framework to assemble the synaptonemal complex (SC) that provides a transient but tight connection between homologous chromosomes. Here, we showed that DESYNAPTIC2 (DSY2), a coiled-coil protein, mediates DSB formation and is directly involved in SC assembly in maize (Zea mays). The dsy2 mutant exhibits homologous pairing defects, leading to sterility. Analyses revealed that DSB formation and the number of RADIATION SENSITIVE51 (RAD51) foci are largely reduced, and synapsis is completely abolished in dsy2 meiocytes. Super-resolution structured illumination microscopy showed that DSY2 is located on the AE and forms a distinct alternating pattern with the HORMA-domain protein ASYNAPTIC1 (ASY1). In the dsy2 mutant, localization of ASY1 is affected, and loading of the central element ZIPPER1 (ZYP1) is disrupted. Yeast two-hybrid and bimolecular fluorescence complementation experiments further demonstrated that ZYP1 interacts with DSY2 but does not interact with ASY1. Therefore, DSY2, an AE protein, not only mediates DSB formation but also bridges the AE and central element of SC during meiosis.
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