ArticleThe Plant cell2015
Nitrogen-Fixing Nodules Are an Important Source of Reduced Sulfur, Which Triggers Global Changes in Sulfur Metabolism in Lotus japonicus.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- An atlas of plant selenium metabolism.The New phytologist · 2026Review
- Flavonol glycosides accumulation in faba bean grown under combined selenium and sulfur application.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Nitrogen-fixing symbiosis induces differential accumulation ofFrontiers in plant science · 2025Article
- Traits linked to natural variation of sulfur content in Arabidopsis thaliana.Journal of experimental botany · 2024Article
- Plant-Environment Response Pathway Regulation Uncovered by Investigating Non-Typical Legume Symbiosis and Nodulation.Plants (Basel, Switzerland) · 2023Review
- An Alkane Sulfonate Monooxygenase Is Required for Symbiotic Nitrogen Fixation byApplied and environmental microbiology · 2019Article
- Sulfate is transported at significant rates through the symbiosome membrane and is crucial for nitrogenase biosynthesis.Plant, cell & environment · 2019Article
- Involvement of Glutaredoxin and Thioredoxin Systems in the Nitrogen-Fixing Symbiosis between Legumes and Rhizobia.Antioxidants (Basel, Switzerland) · 2018Review
- Proteomic analysis dissects the impact of nodulation and biological nitrogen fixation on Vicia faba root nodule physiology.Plant molecular biology · 2018Article
- Impact of overexpression of cytosolic isoform of O-acetylserine sulfhydrylase on soybean nodulation and nodule metabolome.Scientific reports · 2018Article
- Sulfur Transport and Metabolism in Legume Root Nodules.Frontiers in plant science · 2018Review
- A Proteomic View on the Role of Legume Symbiotic Interactions.Frontiers in plant science · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We combined transcriptomic and biochemical approaches to study rhizobial and plant sulfur (S) metabolism in nitrogen (N) fixing nodules (Fix(+)) of Lotus japonicus, as well as the link of S-metabolism to symbiotic nitrogen fixation and the effect of nodules on whole-plant S-partitioning and metabolism. Our data reveal that N-fixing nodules are thiol-rich organs. Their high adenosine 5'-phosphosulfate reductase activity and strong (35)S-flux into cysteine and its metabolites, in combination with the transcriptional upregulation of several rhizobial and plant genes involved in S-assimilation, highlight the function of nodules as an important site of S-assimilation. The higher thiol content observed in nonsymbiotic organs of N-fixing plants in comparison to uninoculated plants could not be attributed to local biosynthesis, indicating that nodules are an important source of reduced S for the plant, which triggers whole-plant reprogramming of S-metabolism. Enhanced thiol biosynthesis in nodules and their impact on the whole-plant S-economy are dampened in plants nodulated by Fix(-) mutant rhizobia, which in most respects metabolically resemble uninoculated plants, indicating a strong interdependency between N-fixation and S-assimilation.
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