ArticleApplied and environmental microbiology2015
Cerium regulates expression of alternative methanol dehydrogenases in Methylosinus trichosporium OB3b.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 91 citations in OpenAlex.
- Synthesis of two methylolanthanin derivatives and the investigation of their lanthanide and iron binding capabilities.Dalton transactions (Cambridge, England : 2003) · 2026Article
- Diversity and distribution of the lanthanome in aerobic methane-oxidising bacteria.Environmental microbiome · 2025Article
- Non-growth substrate ethane perturbs core methanotrophy in obligate methanotrophApplied and environmental microbiology · 2025Article
- Emerging role of rare earth elements in biomolecular functions.The ISME journal · 2025Review
- Direct Methane Oxidation by Copper- and Iron-Dependent Methane Monooxygenases.Chemical reviews · 2024Review
- Different lanthanide elements induce strong gene expression changes in a lanthanide-accumulating methylotroph.Microbiology spectrum · 2023Article
- Identification of a TonB-Dependent Receptor Involved in Lanthanide Switch by the Characterization of Laboratory-Adapted Methylosinus trichosporium OB3b.Applied and environmental microbiology · 2023Article
- Transcriptional Regulation of Methanol Dehydrogenases in the Methanotrophic Bacterium Methylococcus capsulatus Bath by Soluble and Insoluble Lanthanides.Microbes and environments · 2023Article
- Comparative genomic analysis of Methylocystis sp. MJC1 as a platform strain for polyhydroxybutyrate biosynthesis.PloS one · 2023Article
- Methanol utilizers of the rhizosphere and phyllosphere of a common grass and forb host species.Environmental microbiome · 2022Article
- RNA Biomarker Trends across Type I and Type II Aerobic Methanotrophs in Response to Methane Oxidation Rates and Transcriptome Response to Short-Term Methane and Oxygen Limitation in Methylomicrobium album BG8.Microbiology spectrum · 2022Article
- The effect of lanthanum on growth and gene expression in a facultative methanotroph.Environmental microbiology · 2022Article
- Hyperaccumulation of Gadolinium byFrontiers in microbiology · 2022Article
- Siderophore for Lanthanide and Iron Uptake for Methylotrophy and Plant Growth Promotion inFrontiers in microbiology · 2022Article
- Article
- Switching Between Methanol Accumulation and Cell Growth by Expression Control of Methanol Dehydrogenase inFrontiers in microbiology · 2021Article
- Dehydrogenation Mechanism of Three Stereoisomers of Butane-2,3-Diol inFrontiers in bioengineering and biotechnology · 2021Article
- Facultative methanotrophs - diversity, genetics, molecular ecology and biotechnological potential: a mini-review.Microbiology (Reading, England) · 2020Review
- Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function.The Journal of biological chemistry · 2020Article
- Lanthanide-Dependent Methanol and Formaldehyde Oxidation inMicroorganisms · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methanotrophs have multiple methane monooxygenases that are well known to be regulated by copper, i.e., a "copper switch." At low copper/biomass ratios the soluble methane monooxygenase (sMMO) is expressed while expression and activity of the particulate methane monooxygenase (pMMO) increases with increasing availability of copper. In many methanotrophs there are also multiple methanol dehydrogenases (MeDHs), one based on Mxa and another based on Xox. Mxa-MeDH is known to have calcium in its active site, while Xox-MeDHs have been shown to have rare earth elements in their active site. We show here that the expression levels of Mxa-MeDH and Xox-MeDH in Methylosinus trichosporium OB3b significantly decreased and increased, respectively, when grown in the presence of cerium but the absence of copper compared to the absence of both metals. Expression of sMMO and pMMO was not affected. In the presence of copper, the effect of cerium on gene expression was less significant, i.e., expression of Mxa-MeDH in the presence of copper and cerium was slightly lower than in the presence of copper alone, but Xox-MeDH was again found to increase significantly. As expected, the addition of copper caused sMMO and pMMO expression levels to significantly decrease and increase, respectively, but the simultaneous addition of cerium had no discernible effect on MMO expression. As a result, it appears Mxa-MeDH can be uncoupled from methane oxidation by sMMO in M. trichosporium OB3b but not from pMMO.
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