ArticleInternational journal for parasitology2015
Identification and evaluation of vaccine candidate antigens from the poultry red mite (Dermanyssus gallinae).
Article in International journal for parasitology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Recent Advances in Vaccine Development Against Poultry Red Mite (Dermanyssus gallinae): A Literature Review on Native and Recombinant Antigens.Acta parasitologica · 2026Review
- In vivo evaluation of a cytochrome P450 gene from poultry red mite, Dermanyssus gallinae, as a vaccine antigen for chicks.Parasites & vectors · 2026Article
- Pathogenicity analysis and control strategies to combat avian diseases: mechanisms of increased virulence of Marek's disease virus and the development of vaccines against poultry red mites.The Journal of veterinary medical science · 2025Review
- Challenges ofInsects · 2025Review
- Potential of histamine release factor for the utilization as a universal vaccine antigen against poultry red mites, tropical fowl mites, and northern fowl mites.The Journal of veterinary medical science · 2025Article
- How mites influence cage-free egg production in the United States, mite management strategies, and the mitigating role of genomic selection.Animal frontiers : the review magazine of animal agriculture · 2024Article
- Chitinase from Streptomyces mutabilis as an Effective Eco-friendly Biocontrol Agent.Applied biochemistry and biotechnology · 2024Article
- Advances in Non-Chemical Tools to Control Poultry Hematophagous Mites.Veterinary sciences · 2023Review
- Analysis of gene expression in poultry red mite, Dermanyssus gallinae, by RNAscope in situ hybridization.The Journal of veterinary medical science · 2023Article
- Article
- Potential of ferritin 2 as an antigen for the development of a universal vaccine for avian mites, poultry red mites, tropical fowl mites, and northern fowl mites.Frontiers in veterinary science · 2023Article
- Article
- Release of DNA fromAnimals : an open access journal from MDPI · 2022Article
- Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens.Vaccines · 2021Article
- Selection of reference genes for quantitative PCR analysis in poultry red mite (Dermanyssus gallinae).The Journal of veterinary medical science · 2021Article
- Transcriptomic analysis of the poultry red mite, Dermanyssus gallinae, across all stages of the lifecycle.BMC genomics · 2021Article
- RNAi gene knockdown in the poultry red mite, Dermanyssus gallinae (De Geer 1778), a tool for functional genomics.Parasites & vectors · 2021Article
- Characterisation of a cysteine protease from poultry red mites and its potential use as a vaccine for chickens.Parasite (Paris, France) · 2021Article
- A novel cystatin derived from Trichinella spiralis suppresses macrophage-mediated inflammatory responses.PLoS neglected tropical diseases · 2020Article
- Possibilities for IPM Strategies in European Laying Hen Farms for Improved Control of the Poultry Red Mite (Frontiers in veterinary science · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
An aqueous extract of the haematophagous poultry ectoparasite, Dermanyssus gallinae, was subfractionated using anion exchange chromatography. Six of these subfractions were used to immunise hens and the blood from these hens was fed, in vitro, to poultry red mites. Mite mortality following these feeds was indicative of protective antigens in two of the subfractions, with the risks of mites dying being 3.1 and 3.7 times higher than in the control group (P<0.001). A combination of two-dimensional immunoblotting and immunoaffinity chromatography, using IgY from hens immunised with these subfractions, was used in concert with proteomic analyses to identify the strongest immunogenic proteins in each of these subfractions. Ten of the immunoreactive proteins were selected for assessment as vaccine candidates using the following criteria: intensity of immune recognition; likelihood of exposure of the antigen to the antibodies in a blood meal; proposed function and known vaccine potential of orthologous molecules. Recombinant versions of each of these 10 proteins were produced in Escherichia coli and were used to immunise hens. Subsequent in vitro feeding of mites on blood from these birds indicated that immunisation with Deg-SRP-1 (serpin), Deg-VIT-1 (vitellogenin), Deg-HGP-1 (hemelipoglycoprotein) or Deg-PUF-1 (a protein of unknown function) resulted in significantly increased risk of mite death (1.7-2.8times higher than in mites fed blood from control hens immunised with adjuvant only, P<0.001). The potential for using these antigens in a recombinant vaccine is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.