ArticleNeurology2015
Clinical relevance of voltage-gated potassium channel–complex antibodies in children.
Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- CASPR2 antibody-related neurological syndromes in children: three cases report and literature review.BMC pediatrics · 2026Review
- High Relapse Rate in Anti-CASPR2 Disease: Implications for Prolonged Immunotherapy.Neurology(R) neuroimmunology & neuroinflammation · 2026Observational
- Comparison of B Cell Variable Region Gene Segment Characteristics in Neuro-autoantibodies.ImmunoHorizons · 2024Review
- The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis.Molecular psychiatry · 2022Article
- Clinical features, investigations, and outcomes of pediatric limbic encephalitis: A multicenter study.Annals of clinical and translational neurology · 2022Observational
- CHI3L1 in the CSF is a potential biomarker for anti-leucine-rich glioma inactivated 1 encephalitis.Frontiers in immunology · 2022Article
- Developing Consensus in the Assessment and Treatment Pathways for Autoimmune Encephalitis in Child and Adolescent Psychiatry.Frontiers in psychiatry · 2021Article
- Autoimmune Epilepsy - Novel Multidisciplinary Analysis, Discoveries and Insights.Frontiers in immunology · 2021Review
- Clinical Features and Outcomes in Pediatric Autoimmune Encephalitis Associated With CASPR2 Antibody.Frontiers in pediatrics · 2021Article
- Neuropsychiatric Disorders Due to Limbic Encephalitis: Immunologic Aspect.International journal of molecular sciences · 2020Review
- A Tale of Two Brothers: Familial Voltage-Gated Potassium Channel Autoimmune Encephalitis.Cureus · 2020Article
- Pediatric autoimmune encephalitis: Recognition and diagnosis.Neurology(R) neuroimmunology & neuroinflammation · 2020Observational
- Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Understanding Childhood Neuroimmune Diseases of the Central Nervous System.Frontiers in pediatrics · 2019Review
- Article
- Neuroimmune disorders of the central nervous system in children in the molecular era.Nature reviews. Neurology · 2018Review
- Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies.Journal of neurology, neurosurgery, and psychiatry · 2017Article
- Methodological Challenges in Protein Microarray and Immunohistochemistry for the Discovery of Novel Autoantibodies in Paediatric Acute Disseminated Encephalomyelitis.International journal of molecular sciences · 2017Article
- Pediatric Anti-Frontiers in pediatrics · 2017Review
- Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study.The lancet. Psychiatry · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the clinical and immunologic findings in children with voltage-gated potassium channel (VGKC)-complex antibodies (Abs).
methodsThirty-nine of 363 sera, referred from 2 pediatric centers from 2007 to 2013, had been reported positive (.100 pM) for VGKC-complex Abs. Medical records were reviewed retrospectively and the patients’ condition was independently classified as inflammatory (n 5 159) or noninflammatory (n 5 204). Positive sera (.100 pM) were tested/retested for the VGKC complex Ab–positive complex proteins LGI1 and CASPR2, screened for binding to live hippocampal neurons, and 12 high-titer sera (.400 pM) tested by radioimmunoassay for binding to VGKC Kv1 subunits with or without intracellular postsynaptic density proteins.
resultsVGKC-complex Abs were found in 39 children, including 20% of encephalopathies and 7.6% of other conditions (p 5 0.001). Thirty children had inflammatory conditions and 9 had noninflammatory etiologies but titers.400 pM (n512) were found only in inflammatory diseases (p , 0.0001). Four sera, including from 2 children with coexisting NMDA receptor Abs and one with Guillain-Barré syndrome and Abs to both LGI1 and CASPR2, bound to hippocampal neurons. None of the sera bound detectably to VGKC Kv1 subunits on live HEK cells, but 4 of 12 .400 pM sera immunoprecipitated VGKC Kv1 subunits, with or without postsynaptic densities, extracted from transfected cells.
conclusionPositive VGKC-complex Abs cannot be taken to indicate a specific clinical syndrome in children, but appear to be a nonspecific biomarker of inflammatory neurologic diseases, particularly of encephalopathy. Some of the Abs may bind to intracellular epitopes on the VGKC subunits, or to the intracellular interacting proteins, but in many the targets remain undefined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.