ArticleWorld journal of urology2016
The correlation between the electrode configuration and histopathology of irreversible electroporation ablations in prostate cancer patients.
Article in World journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01790451 (The Safety and Efficacy of Irreversible Electroporation for the Ablation of Prostate Cancer Assessed by Procedural Related Side Effects and Post Prostatectomy Histology), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Safety and Efficacy of Irreversible Electroporation for the Ablation of Prostate Cancer Assessed by Procedural Related Side Effects and Post Prostatectomy Histology: A Prospective Human In-Vivo Study.
Who cites it
30 citing papers in PubMed, 69 citations in OpenAlex.
- First Human Trial of High-Frequency Irreversible Electroporation Therapy for Prostate Cancer.Technology in cancer research & treatment · 2018Trial
- MRI and contrast-enhanced ultrasound imaging for evaluation of focal irreversible electroporation treatment: results from a phase I-II study in patients undergoing IRE followed by radical prostatectomy.European radiology · 2016Trial
- Focal vs extended ablation in localized prostate cancer with irreversible electroporation; a multi-center randomized controlled trial.BMC cancer · 2016Trial
- Safety and Efficacy of Irreversible Electroporation in the Treatment of Lesions Near or Involving Gastrointestinal Structures.Cardiovascular and interventional radiology · 2026Article
- Irreversible Electroporation for the Focal Treatment of Prostate Cancer: A Systematic Review.The world journal of men's health · 2025Article
- Personalized Treatment Strategy in "Low-Risk Prostate Cancer Active Surveillance Candidates" Using Irreversible Electroporation: Prospective Evaluation of Feasibility, Morbidity, Functional and Oncological Outcomes.The world journal of men's health · 2024Article
- A multi-center international study to evaluate the safety, functional and oncological outcomes of irreversible electroporation for the ablation of prostate cancer.Prostate cancer and prostatic diseases · 2024Article
- Article
- Outcomes of salvage radical prostatectomy after initial irreversible electroporation treatment for recurrent prostate cancer.BJU international · 2022Article
- Article
- Invasive and non-invasive electrodes for successful drug and gene delivery in electroporation-based treatments.Frontiers in bioengineering and biotechnology · 2022Review
- A Theoretical Argument for Extended Interpulse Delays in Therapeutic High-Frequency Irreversible Electroporation Treatments.IEEE transactions on bio-medical engineering · 2021Article
- Targeting the cancer lesion, not the whole prostate.Translational andrology and urology · 2020Review
- Focal therapy, time to join the multi-disciplinary team discussion?Translational andrology and urology · 2020Review
- Application of three-dimensional printing in interventional medicine.Journal of interventional medicine · 2020Article
- Irreversible Electroporation: Background, Theory, and Review of Recent Developments in Clinical Oncology.Bioelectricity · 2019Review
- Interventional therapy in malignant conditions of the prostate.Der Radiologe · 2019Review
- Impact on genitourinary function and quality of life following focal irreversible electroporation of different prostate segments.Diagnostic and interventional radiology (Ankara, Turkey) · 2018Article
- Focal therapy for localized prostate cancer: is there a "middle ground" between active surveillance and definitive treatment?Asian journal of andrology · 2018Article
- High-Frequency Irreversible Electroporation for Intracranial Meningioma: A Feasibility Study in a Spontaneous Canine Tumor Model.Technology in cancer research & treatment · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIrreversible electroporation (IRE) is a novel minimally invasive therapy for prostate cancer using short electric pulses to ablate prostate tissue. The purpose of this study is to determine the IRE effects in prostate tissue and correlate electrode configuration with the histology of radical prostatectomy (RP) specimens. We hypothesize that the area within the electrode configuration is completely ablated and that the area within the electrode configuration is predictive for the ablated area after treatment.
methodsA prospective phase I/II study was conducted in 16 consecutive patients with histopathologically confirmed prostate cancer scheduled for RP. Focal or extended IRE treatment of the prostate was performed 4 weeks prior to RP. The locations of the electrodes were used to calculate the planned ablation zone. Following RP, the specimens were processed into whole-mount sections, histopathology (PA) was assessed and ablation zones were delineated. The area of the tissue alteration was determined by measuring the surface. The planned and the histological ablation zones were compared, analysed per individual patient and per protocol (focal vs. extended).
resultsAll cells within the electrode configuration were completely ablated and consisted only of necrotic and fibrotic tissue without leaving any viable cells. The histological ablation zone was always larger than the electrodes configuration (2.9 times larger for the 3 electrodes configuration and 2.5 times larger for the ≥4 electrode configuration). These ablation effects extended beyond the prostatic capsule in the neurovascular bundle in 13 out of 15 cases.
conclusionsIRE in prostate cancer results in completely ablated, sharply demarcated lesions with a histological ablation zone beyond the electrode configuration. No skip lesions were observed within the electrode configuration. CLINICAL TRIALS: ClinicalTrials.gov Identifier: NCT01790451 https://clinicaltrials.gov/ct2/show/NCT01790451.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.