Evidence map›Paper›PMID 26296321›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2015

eMouseAtlas informatics: embryo atlas and gene expression database.

Chris Armit, Lorna Richardson, Bill Hill, Yiya Yang, Richard A Baldock

Abstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Mid-Gestation lethality ofInternational journal of molecular sciences · 2020
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. The 'straight mouse': defining anatomical axes in 3D embryo models.Database : the journal of biological databases and curation · 2017
    Article
  12. Leveraging Online Resources to Prioritize Candidate Genes for Functional Analyses: Using the Fetal Testis as a Test Case.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2017
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chris ArmitMRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Lorna RichardsonMRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Bill HillMRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Yiya YangMRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Richard A BaldockMRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland. Richard.Baldock@igmm.ed.ac.uk.

Funding

Medical Research Council MC_PC_U127527203
6 · The paper itself

Abstract

A significant proportion of developmental biology data is presented in the form of images at morphologically diverse stages of development. The curation of these datasets presents different challenges to that of sequence/text-based data. Towards this end, the eMouseAtlas project created a digital atlas of mouse embryo development as a means of understanding developmental anatomy and exploring the relationship between genes and development in a spatial context. Using the morphological staging system pioneered by Karl Theiler, the project has generated 3D models of post-implantation mouse development and used them as a spatial framework for the delineation of anatomical components and for archiving in situ gene expression data in the EMAGE database. This has allowed us to develop a unique online resource for mouse developmental biology. We describe here the underlying structure of the resource, as well as some of the tools that have been developed to allow users to mine the curated image data. These tools include our IIP3D/X3DOM viewer that allows 3D visualisation of anatomy and/or gene expression in the context of a web browser, and the eHistology resource that extends this functionality to allow visualisation of high-resolution cellular level images of histology sections. Furthermore, we review some of the informatics aspects of eMouseAtlas to provide a deeper insight into the use of the atlas and gene expression database.

Indexed as

Computational BiologyDatabases, GeneticEmbryonic DevelopmentAnimalsEmbryo, MammalianGene Expression Regulation, DevelopmentalInternetMiceSoftware

Identifiers

PMID26296321
PMCPMC4602050

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.