ArticleJournal of neuroscience methods2015
Strategies for optical control and simultaneous electrical readout of extended cortical circuits.
Article in Journal of neuroscience methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Towards maximizing optical access through Smart Dura.Journal of neural engineering · 2026Article
- Artifact-free, colocalized opto-electrophysiology enabled by a flexible, multimodal interface integrating transparent MXene microelectrodes and microLEDs.Biosensors & bioelectronics · 2026Article
- Multimodal Optical Imaging and Modulation with Simultaneous Electrophysiology Through Smart Dura in Non-Human Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Inferring Neural Communication Dynamics from Field Potentials Using Graph Diffusion Autoregression.bioRxiv : the preprint server for biology · 2025Article
- Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents.Journal of visualized experiments : JoVE · 2025Article
- Innovating beyond electrophysiology through multimodal neural interfaces.Nature reviews electrical engineering · 2025Article
- Integrated Microprism and Microelectrode Array for Simultaneous Electrophysiology and Two-Photon Imaging across All Cortical Layers.Advanced healthcare materials · 2024Article
- High-density transparent graphene arrays for predicting cellular calcium activity at depth from surface potential recordings.Nature nanotechnology · 2024Article
- Transparent and Stretchable Au─Ag Nanowire Recording Microelectrode Arrays.Advanced materials technologies · 2023Article
- Review
- Behavioral optogenetics in nonhuman primates; a psychological perspective.Current research in neurobiology · 2023Review
- Transparent neural interfaces: challenges and solutions of microengineered multimodal implants designed to measure intact neuronal populations using high-resolution electrophysiology and microscopy simultaneously.Microsystems & nanoengineering · 2023Review
- Improving the Efficacy and Accessibility of Intracranial Viral Vector Delivery in Non-Human Primates.Pharmaceutics · 2022Article
- Demonstration of an Optimized Large-scale Optogenetic Cortical Interface for Non-human Primates.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2022Article
- Network structure mediates functional reorganization induced by optogenetic stimulation of non-human primate sensorimotor cortex.iScience · 2022Article
- A versatile toolbox for studying cortical physiology in primates.Cell reports methods · 2022Article
- Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Multi-modal artificial dura for simultaneous large-scale optical access and large-scale electrophysiology in non-human primate cortex.Journal of neural engineering · 2021Article
- Sufficient sampling for kriging prediction of cortical potential in rat, monkey, and human µECoG.Journal of neural engineering · 2021Article
- An Open Resource for Non-human Primate Optogenetics.Neuron · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundTo dissect the intricate workings of neural circuits, it is essential to gain precise control over subsets of neurons while retaining the ability to monitor larger-scale circuit dynamics. This requires the ability to both evoke and record neural activity simultaneously with high spatial and temporal resolution. NEW
methodIn this paper we present approaches that address this need by combining micro-electrocorticography (μECoG) with optogenetics in ways that avoid photovoltaic artifacts.
resultsWe demonstrate that variations of this approach are broadly applicable across three commonly studied mammalian species - mouse, rat, and macaque monkey - and that the recorded μECoG signal shows complex spectral and spatio-temporal patterns in response to optical stimulation. COMPARISON WITH EXISTING
methodsWhile optogenetics provides the ability to excite or inhibit neural subpopulations in a targeted fashion, large-scale recording of resulting neural activity remains challenging. Recent advances in optical physiology, such as genetically encoded Ca(2+) indicators, are promising but currently do not allow simultaneous recordings from extended cortical areas due to limitations in optical imaging hardware.
conclusionsWe demonstrate techniques for the large-scale simultaneous interrogation of cortical circuits in three commonly used mammalian species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.