Evidence map›Paper›PMID 26296098›Full record

ArticleNanomedicine (London, England)2015

Targeting breast cancer with sugar-coated carbon nanotubes.

Cale D Fahrenholtz, Mallinath Hadimani, S Bruce King, Suzy V Torti, Ravi Singh

Open access · greenAbstract read
In one paragraph

Article in Nanomedicine (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Nanoparticle-mediated targeted drug delivery for breast cancer treatment.Biochimica et biophysica acta. Reviews on cancer · 2019
    Review
  6. Review
  7. Article
  8. Carbon nanotubes as anti-bacterial agents.Cellular and molecular life sciences : CMLS · 2017
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Cale D FahrenholtzDepartment of Cancer Biology, Wake Forest University Health Sciences, Hanes Bldg, Rm 4045, Medical Center Blvd, Winston Salem, NC 27157, USA.
Mallinath HadimaniDepartment of Chemistry, Wake Forest University, Winston Salem, NC 27109, USA.
S Bruce KingDepartment of Chemistry, Wake Forest University, Winston Salem, NC 27109, USA.
Suzy V TortiDepartment of Molecular Biology & Biophysics, University of Connecticut Health Center, CT 06030, USA.
Ravi SinghDepartment of Cancer Biology, Wake Forest University Health Sciences, Hanes Bldg, Rm 4045, Medical Center Blvd, Winston Salem, NC 27157, USA.
Wake Forest University · USUConn Health · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Training Program in Cancer BiologyT32CA079448 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRIDEL, STEVEN J. · 2000 to 2014
$6.5M
Nanotubes in tumor imaging and therapyR01CA128428 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TORTI, SUZY V · 2008 to 2011
$1.5M
Tumor Targeting and Diagnostic Applications of Glycosylated NanotubesR00CA154006 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SINGH, RAVI N · 2012 to 2014
$697k
Tumor Targeting and Diagnostic Applications of Glycosylated NanotubesK99CA154006 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SINGH, RAVI N · 2010 to 2011
$257k
NCI NIH HHS K99 CA154006NCI NIH HHS P30 CA012197NCI NIH HHS P30CA012197NCI NIH HHS R00 CA154006NCI NIH HHS R00CA154006NCI NIH HHS R01CA12842NCI NIH HHS R01 CA128428NCI NIH HHS R01CA128428-02S1NCI NIH HHS T32 CA079448NCI NIH HHS T32CA079448
6 · The paper itself

Abstract

aimsTo evaluate the use of glucosamine functionalized multiwalled carbon nanotubes (glyco-MWCNTs) for breast cancer targeting. MATERIALS &

methodsTwo types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potential to bind and target breast cancer cells in vitro and in vivo. RESULTS &

conclusionBinding of glyco-MWCNTs in breast cancer cells is mediated by specific interaction with glucose transporters. Glyco-MWCNTs prepared by non-covalent coating with phospholipid-glucosamine displayed an extended blood circulation time, delayed urinary clearance, low tissue retention and increased breast cancer tumor accumulation in vivo. These studies lay the foundation for development of a cancer diagnostic agent based upon glyco-MWCNTs with the potential for superior accuracy over current radiopharmaceuticals.

Indexed as

Nanotubes, CarbonAnimalsCarbohydratesCell Line, TumorMammary Neoplasms, ExperimentalMiceTissue DistributionCarbohydratesNanotubes, Carbonbiocompatibilityimagingmetabolismnanoparticleself-assembly

Identifiers

PMID26296098
PMCPMC4610120
OpenAlexW1912646463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.