ArticlePhysics in medicine and biology2015
Anatomical-based partial volume correction for low-dose dedicated cardiac SPECT/CT.
Article in Physics in medicine and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Critical review of partial volume correction methods in PET and SPECT imaging: benefits, pitfalls, challenges, and future outlook.European journal of nuclear medicine and molecular imaging · 2026Review
- Partial volume correction for Lu-177-PSMA SPECT.EJNMMI physics · 2024Article
- Segmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network.IEEE transactions on medical imaging · 2023Article
- Nuclear Cardiac Imaging in the Interventional Suite.Current cardiology reports · 2022Review
- Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Cardiac motion correction for improving perfusion defect detection in cardiac SPECT at standard and reduced doses of activity.Physics in medicine and biology · 2019Article
- Quantification of intramyocardial blood volume withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Non-invasive measures of coronary microcirculation: Taking the long road to the clinic.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT.Physics in medicine and biology · 2017Article
- Noise suppressed partial volume correction for cardiac SPECT/CT.Medical physics · 2016Article
- The impact of system matrix dimension on small FOV SPECT reconstruction with truncated projections.Medical physics · 2016Article
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Authors and funding
9 authors.
Funding
Abstract
Due to the limited spatial resolution, partial volume effect has been a major degrading factor on quantitative accuracy in emission tomography systems. This study aims to investigate the performance of several anatomical-based partial volume correction (PVC) methods for a dedicated cardiac SPECT/CT system (GE Discovery NM/CT 570c) with focused field-of-view over a clinically relevant range of high and low count levels for two different radiotracer distributions. These PVC methods include perturbation geometry transfer matrix (pGTM), pGTM followed by multi-target correction (MTC), pGTM with known concentration in blood pool, the former followed by MTC and our newly proposed methods, which perform the MTC method iteratively, where the mean values in all regions are estimated and updated by the MTC-corrected images each time in the iterative process. The NCAT phantom was simulated for cardiovascular imaging with (99m)Tc-tetrofosmin, a myocardial perfusion agent, and (99m)Tc-red blood cell (RBC), a pure intravascular imaging agent. Images were acquired at six different count levels to investigate the performance of PVC methods in both high and low count levels for low-dose applications. We performed two large animal in vivo cardiac imaging experiments following injection of (99m)Tc-RBC for evaluation of intramyocardial blood volume (IMBV). The simulation results showed our proposed iterative methods provide superior performance than other existing PVC methods in terms of image quality, quantitative accuracy, and reproducibility (standard deviation), particularly for low-count data. The iterative approaches are robust for both (99m)Tc-tetrofosmin perfusion imaging and (99m)Tc-RBC imaging of IMBV and blood pool activity even at low count levels. The animal study results indicated the effectiveness of PVC to correct the overestimation of IMBV due to blood pool contamination. In conclusion, the iterative PVC methods can achieve more accurate quantification, particularly for low count cardiac SPECT studies, typically obtained from low-dose protocols, gated studies, and dynamic applications.
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