ReviewMarine drugs2015
Silaffins in Silica Biomineralization and Biomimetic Silica Precipitation.
Review in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 127 citations in OpenAlex.
- Diatom Biosilica: Extraction Techniques and Applications in Energy Storage and Conversion Devices.ChemSusChem · 2026Review
- Elucidation of the aragonite nanofiber formation mechanism of LICP contained in the hinge ligament ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- A Multifunctional Peptide Linker Stably Anchors to Silica Spicules and Enables MMP-Responsive Release of Diverse Bioactive Cargos.Micromachines · 2026Article
- Biological and Biologically Inspired Functional Nanostructures: Insights into Structural, Optical, Thermal, and Sensing Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Prospects and problems in enzyme immobilization methodology: comprehensive review.Biophysical reviews · 2025Review
- Formation of Hybrid Spherical Silica Particles Using a Novel Alkoxy-Functional Polysilsesquioxane Macromonomer as a Precursor in an Acid-Catalyzed Sol-Gel Process.Materials (Basel, Switzerland) · 2025Article
- Exploiting Silica-Binding and Silica-Forming Proteins as Versatile Tools for One-Step Enzyme Immobilization on Siliceous Materials.International journal of molecular sciences · 2025Review
- Understanding Biomineralization Mechanisms to Produce Size-Controlled, Tailored Nanocrystals for Optoelectronic and Catalytic Applications: A Review.ACS applied nano materials · 2024Review
- An Atomistic View on the Mechanism of Diatom Peptide-Guided Biomimetic Silica Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Harnessing the power of thermosensitive liposomes with gold nanoprisms and silica for controlled drug delivery in combined chemotherapy and phototherapy.RSC advances · 2024Article
- Modification of Living Diatom,ACS applied bio materials · 2024Article
- Biomineral-Based Composite Materials in Regenerative Medicine.International journal of molecular sciences · 2024Review
- Diatom-inspired silicification process for development of green flexible silica composite aerogels.Scientific reports · 2024Article
- Biomimetic Sol-Gel Chemistry to Tailor Structure, Properties, and Functionality of Bionanocomposites by Biopolymers and Cells.Materials (Basel, Switzerland) · 2023Review
- Microbially induced precipitation of silica by anaerobic methane-oxidizing consortia and implications for microbial fossil preservation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Self-Entrapment of Antimicrobial Peptides in Silica Particles for Stable and Effective Antimicrobial Peptide Delivery System.International journal of molecular sciences · 2023Article
- Biomimetic Silica Particles with Self-Loading BMP-2 Knuckle Epitope Peptide and Its Delivery for Bone Regeneration.Pharmaceutics · 2023Article
- Understanding Self-Assembly of Silica-Precipitating Peptides to Control Silica Particle Morphology.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Biocatalytic synthesis and ordered self-assembly of silica nanoparticles via a silica-binding peptide.Beilstein journal of nanotechnology · 2023Article
- A Biomimetic, Silaffin R5-Based Antigen Delivery Platform.Pharmaceutics · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomineralization processes leading to complex solid structures of inorganic material in biological systems are constantly gaining attention in biotechnology and biomedical research. An outstanding example for biomineral morphogenesis is the formation of highly elaborate, nano-patterned silica shells by diatoms. Among the organic macromolecules that have been closely linked to the tightly controlled precipitation of silica in diatoms, silaffins play an extraordinary role. These peptides typically occur as complex posttranslationally modified variants and are directly involved in the silica deposition process in diatoms. However, even in vitro silaffin-based peptides alone, with and without posttranslational modifications, can efficiently mediate biomimetic silica precipitation leading to silica material with different properties as well as with encapsulated cargo molecules of a large size range. In this review, the biomineralization process of silica in diatoms is summarized with a specific focus on silaffins and their in vitro silica precipitation properties. Applications in the area of bio- and nanotechnology as well as in diagnostics and therapy are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.