Trial reportThe Clinical journal of pain2016
The SPADE Symptom Cluster in Primary Care Patients With Chronic Pain.
Trial report in The Clinical journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Social determinants of health as predictors of latent symptom clusters in patients undergoing maintenance hemodialysis: A secondary analysis of the HOPE consortium randomized trial.The journal of pain · 2026Trial
- Performance of the Healthy Aging Brain Care Monitor Self Report in Monitoring Post-Intensive Care Syndrome Among Acute Respiratory Failure Survivors.Critical care medicine · 2025Trial
- Clinical Characterization of Juvenile Fibromyalgia in a Multicenter Cohort of Adolescents Enrolled in a Randomized Clinical Trial.Arthritis care & research · 2023Trial
- Prevalence, Severity, and Co-Occurrence of SPPADE Symptoms in 31,866 Patients With Cancer.Journal of pain and symptom management · 2023Trial
- Testing a newly developed activity pacing framework for chronic pain/fatigue: a feasibility study.BMJ open · 2021Trial
- Sleep Disturbance Predicts Less Improvement in Pain Outcomes: Secondary Analysis of the SPACE Randomized Clinical Trial.Pain medicine (Malden, Mass.) · 2020Trial
- Incorporating PROMIS Symptom Measures into Primary Care Practice-a Randomized Clinical Trial.Journal of general internal medicine · 2018Trial
- Article
- Pilot implementation and evaluation of a social risk screening tool for hospitalised patients in Singapore.Journal of hospital medicine · 2026Article
- Symptom cluster profiles in adolescents with inflammatory bowel disease: Cross-sectional study using ImproveCareNow data.Journal of pediatric gastroenterology and nutrition · 2026Article
- Neural and psychosocial signatures of the comorbidity between pain and affective symptoms.Pain reports · 2026Article
- From reporting to relating: Reimagining ePROMs in cancer symptom management.Social science & medicine (1982) · 2026Article
- Association of Chronic Kidney Disease-Associated Pruritus With the Sleep Disturbance, Depression, Pain, Anxiety, and Low Energy/Fatigue Symptom Cluster: A Retrospective Cohort Study.Kidney medicine · 2026Article
- Social wellbeing, loneliness, and symptom burden in head and neck cancer survivors: a latent class analysis.Journal of psychosocial oncology · 2026Article
- Self-report of symptom cluster experiences in cancer patient-caregiver dyads.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Stigma, social support, and spirituality: associations with symptoms among Black, Latina, and Chinese American cervical cancer survivors.Journal of cancer survivorship : research and practice · 2024Article
- A network analysis of pain intensity and pain-related measures of physical, emotional, and social functioning in US military service members with chronic pain.Pain medicine (Malden, Mass.) · 2024Article
- Systematic symptom management in the IMPACT Consortium: rationale and design for 3 effectiveness-implementation trials.JNCI cancer spectrum · 2023Article
- Psychoneurological symptom cluster trajectories in individuals treated for early-stage breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Predictors of psychoneurological symptoms in cancer caregivers over time: Role of caregiving burden, stress, and patient symptoms.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesSleep disturbance, pain, anxiety, depression, and low energy/fatigue, the SPADE pentad, are the most prevalent and co-occurring symptoms in the general population and clinical practice. Co-occurrence of SPADE symptoms may produce additive impairment and negatively affect treatment response, potentially undermining patients' health and functioning. The purpose of this paper is to determine: (1) prevalence and comorbidity (ie, clustering) of SPADE symptoms; (2) internal reliability and construct validity of a composite SPADE symptom score derived from the Patient-Reported Outcomes Measurement Information System (PROMIS) measures; and (3) whether improvement in somatic symptom burden represented by a composite score predicted subsequent measures of functional status at 3 and 12 months follow-up.
methodsSecondary analysis of data from the Stepped Care to Optimize Pain care Effectiveness study, a randomized trial of a collaborative care intervention for Veterans with chronic pain.
resultsMost patients had multiple SPADE symptoms; only 9.6% of patients were monosymptomatic. The composite PROMIS symptom score had good internal reliability (Cronbach's alpha=0.86) and construct validity and strongly correlated with multiple measures of functional status; improvement in the composite score significantly correlated with higher scores for 5 of 6 functional status outcomes. The standardized error of measurement (SEM) for the composite T-score was 2.84, suggesting a 3-point difference in an individual's composite score may be clinically meaningful. DISCUSSION: Brief PROMIS measures may be useful in evaluating SPADE symptoms and overall symptom burden. Because symptom burden may predict functional status outcomes, better identification and management of comorbid symptoms may be warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.