Evidence map›Paper›PMID 26295375›Full record

ReviewJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2015

The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes.

Alexander Marx, John K C Chan, Jean-Michel Coindre, Frank Detterbeck, Nicolas Girard, Nancy L Harris, Elaine S Jaffe, Michael O Kurrer, Edith M Marom, Andre L Moreira and 3 more

Abstract readReview
In one paragraph

Review in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 312 papers.

0numbers the graph read from it
0cells of the map it votes in
312citing papers in PubMed
23.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

312 citing papers in PubMed, 598 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. [Cancers · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

252 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 6 countries.

Alexander Marx*Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany; †Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China; ‡Department of Pathology, Institut Bergonié, Bordeaux, France; §Department of Thoracic Surgery, Yale University School of Medicine, New Haven, Connecticut; ‖Department of Respiratory Medicine, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France; ¶Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; #Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; **Gemeinschaftspraxis für Pathologie, Zurich, Switzerland; ††Department of Diagnostic Imaging, The Chaim Sheba Medical Center, Tel Hashomer, Israel; ‡‡Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York; §§Department of Diagnostic Pathology, Saiseikai Central Hospital, Tokyo, Japan; ‖‖Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, New York; and ¶¶Department of Pathology, Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.
John K C Chan
Jean-Michel Coindre
Frank Detterbeck
Nicolas Girard
Nancy L Harris
Elaine S Jaffe
Michael O Kurrer
Edith M Marom
Andre L Moreira
Kiyoshi Mukai
Attilio Orazi
Philipp Ströbel
Heidelberg University · DEHospices Civils de Lyon · FRInstitut Bergonié · FRMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · USNational Cancer Institute · USNewYork–Presbyterian Hospital · USQueen Elizabeth Hospital · CNSaiseikai Central Hospital · JPSheba Medical Center · ILUniversitätsmedizin Göttingen · DEYale University · US

Funding

Hematopathology DiagnosisZIABC011070 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$14.5M
Hematopathology diagnosis and educationZ01BC011070 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2008 to 2008
$737k
Intramural NIH HHS Z01 BC011070
6 · The paper itself

Abstract

This overview of the 4th edition of the World Health Organization (WHO) Classification of thymic tumors has two aims. First, to comprehensively list the established and new tumor entities and variants that are described in the new WHO Classification of thymic epithelial tumors, germ cell tumors, lymphomas, dendritic cell and myeloid neoplasms, and soft-tissue tumors of the thymus and mediastinum; second, to highlight major differences in the new WHO Classification that result from the progress that has been made since the 3rd edition in 2004 at immunohistochemical, genetic and conceptual levels. Refined diagnostic criteria for type A, AB, B1-B3 thymomas and thymic squamous cell carcinoma are given, and it is hoped that these criteria will improve the reproducibility of the classification and its clinical relevance. The clinical perspective of the classification has been strengthened by involving experts from radiology, thoracic surgery, and oncology; by incorporating state-of-the-art positron emission tomography/computed tomography images; and by depicting prototypic cytological specimens. This makes the thymus section of the new WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart a valuable tool for pathologists, cytologists, and clinicians alike. The impact of the new WHO Classification on therapeutic decisions is exemplified in this overview for thymic epithelial tumors and mediastinal lymphomas, and future perspectives and challenges are discussed.

Indexed as

HumansNeoplasm GradingNeoplasm StagingThymomaThymus NeoplasmsWorld Health Organization

Identifiers

PMID26295375
PMCPMC4581965
OpenAlexW1875240237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.