ArticleChemical communications (Cambridge, England)2015
Synthesis of double-clickable functionalised graphene oxide for biological applications.
Article in Chemical communications (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Simultaneous Electrochemical Exfoliation of Graphite and Formation of Azide-Functionalized Graphene Flakes and Their Application in Sensing.ACS omega · 2026Article
- Graphene Oxide Nanosheets Toxicity in Mice Is Dependent on Protein Corona Composition and Host Immunity.ACS nano · 2024Article
- Recent advances in the functionalization, substitutional doping and applications of graphene/graphene composite nanomaterials.RSC advances · 2024Review
- Fluorescence Microscopy-An Outline of Hardware, Biological Handling, and Fluorophore Considerations.Cells · 2021Review
- Fabrication and Characterization of a Biomaterial Based on Extracellular-Vesicle Functionalized Graphene Oxide.Frontiers in bioengineering and biotechnology · 2021Article
- Is carboxylation an efficient method for graphene oxide functionalization?Nanoscale advances · 2020Article
- Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio-Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines.Advanced materials (Deerfield Beach, Fla.) · 2018Article
- Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood-brain barrier in vitro and in vivo.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- Click Chemistry-Mediated Nanosensors for Biochemical Assays.Theranostics · 2016Review
- Towards the Synthesis of Graphene Azide from Graphene Oxide.Molecules (Basel, Switzerland) · 2015Article
- Solvent-Free Click-Mechanochemistry for the Preparation of Cancer Cell Targeting Graphene Oxide.ACS applied materials & interfaces · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Azide- and alkyne-double functionalised graphene oxide (Click(2) GO) was synthesised and characterised with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), thermogravimetric analysis (TGA) and Raman spectroscopy. Fourteen-percentage increase in azide content was found, after pre-treatment of GO with meta-chloroperoxybenzoic acid (mCPBA), determined with elemental analysis. No effect on A549 cell viability was found, up to 100 μg mL(-1) and 72 h of incubation, determined with the modified lactate dehydrogenase (mLDH) assay. Two sequential copper(i) catalysed azide-alkyne cycloaddition (CuAAC) reactions were performed to conjugate the propargyl-modified blood-brain barrier targeting peptide Angiopep-2, and a bis-azide polyethylene glycol (MW = 3500), to the Click(2) GO. The final conjugate was characterised with ATR-FTIR and TGA.
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