ArticleScience advances2015
Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation.
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Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 1 of them a synthesis that pooled it.
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129citing papers in PubMed, 1 pooled it
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Who cites it
129 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology.Cardiovascular research · 2019Guideline
- Statin-induced microRNAome alterations modulating inflammation pathways of peripheral blood mononuclear cells in patients with hypercholesterolemia.Bioscience reports · 2020Trial
- S100A8/A9 and S100A12 Proteins and Macrophage Polarization: Therapeutic Targets in Atherosclerosis.Biomolecules · 2026Review
- CD47 Blockade Reprograms the Monocyte-Macrophage Axis to Promote Inflammation Resolution in Atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- A Mathematical Model for Smooth Muscle Cell Phenotype Switching In Atherosclerotic Plaque.Bulletin of mathematical biology · 2026Article
- The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- How Advanced is Nanomedicine to Treat Atherosclerosis? A Comprehensive Review of the Literature.International journal of nanomedicine · 2026Review
- Immunometabolism drives metabolic and infectious disease progression through bidirectional metabolic reprogramming and epigenetic remodeling.Frontiers in immunology · 2026Review
- Engineered immune-driven theranostics for clinical cardiology.Military Medical Research · 2025Review
- GATA2 Mediates Macrophage Proliferation During Atherosclerosis.Journal of the American Heart Association · 2025Article
- Orally deliverable biomimetic nucleic acid therapies for targeted treatment of atherosclerosis.Acta pharmaceutica Sinica. B · 2025Article
- A programmable platelet theranostic platform for adaptive multi-stage delivery and synergistic immunotherapy in atherosclerosis.Nature communications · 2025Article
- The role of ketone bodies in oxidized LDL-induced cell proliferation and lipid accumulation of macrophages.International journal of experimental pathology · 2025Article
- Metabolic adaptations driving innate immune memory: mechanisms and therapeutic implications.Journal of leukocyte biology · 2025Review
- A review on plant-mediated synthesis of AgNPs and their formulations for wound healing application.Molecular biology reports · 2025Review
- Microfluidic Perfusable Pathological Vasculature for Atherosclerosis Drug Screening.Research (Washington, D.C.) · 2025Article
- Anti-atherosclerotic effects and molecular targets of salvianolic acids fromFrontiers in pharmacology · 2025Review
- Olfr2-positive macrophages originate from monocytes proliferate in situ and present a pro-inflammatory foamy-like phenotype.Cardiovascular research · 2024Article
- Dual-Function Nanoscale Coordination Polymer Nanoparticles for Targeted Diagnosis and Therapeutic Delivery in Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment.Nature nanotechnology · 2024Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Jun TangTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA ; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mark E LobattoTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA ; Department of Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
Laurien HassingTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA ; Department of Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
Susanne van der StaayTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA ; Department of Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
Sarian M van RijsTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA ; Department of Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
Claudia CalcagnoTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA.
Mounia S BrazaTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA.
Samantha BaxterTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA.
Francois FayTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA.
Brenda L Sanchez-GaytanTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA.
Raphaël DuivenvoordenDepartment of Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
Hendrik SagerCenter for Systems Biology, Massachusetts General Hospital, and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02114, USA.
Yaritzy M AstudilloDepartment of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, NYU School of Medicine, New York, NY 10016, USA.
Wei LeongTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA ; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sarayu RamachandranTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA.
Gert StormDepartment of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands ; Department of Controlled Drug Delivery, MIRA Institute for Biomedical Engineering and Technical Medicine, University of Twente, 7500 AE Enschede, The Netherlands.
Carlos Pérez-MedinaTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA.
Thomas ReinerDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10065.
David P CormodeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gustav J StrijkersDepartment of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands.
Erik S G StroesDepartment of Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
Filip K SwirskiCenter for Systems Biology, Massachusetts General Hospital, and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02114, USA.
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital, and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02114, USA.
Edward A FisherDepartment of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, NYU School of Medicine, New York, NY 10016, USA.
Zahi A FayadTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA.
Willem J M MulderTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York 10029, NY, USA ; Department of Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTheranostic HDL nanoparticles for inflammatory macrophages in atherosclerosisR01EB009638 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2009 to 2016
$4.6MPET/MRI to study nanotherapy in atherosclerosisR01HL125703 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, WILLEM · 2015 to 2018
$2.4MAnti-inflammatory nanoparticle formulations to treat atherosclerosisR01HL118440 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, WILLEM, NAHRENDORF, MATTHIAS · 2014 to 2017
$2.3MA Surface Activable Nanoemulsion platform for Breast Cancer Diagnosis and TherapyR01CA155432 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, WILLEM · 2011 to 2015
$1.7MNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA155432NHLBI NIH HHS HHSN268201000045CNHLBI NIH HHS R01 HL118440NHLBI NIH HHS R01 HL125703NIBIB NIH HHS R01 EB009638
Abstract
Inflammation drives atherosclerotic plaque progression and rupture, and is a compelling therapeutic target. Consequently, attenuating inflammation by reducing local macrophage accumulation is an appealing approach. This can potentially be accomplished by either blocking blood monocyte recruitment to the plaque or increasing macrophage apoptosis and emigration. Because macrophage proliferation was recently shown to dominate macrophage accumulation in advanced plaques, locally inhibiting macrophage proliferation may reduce plaque inflammation and produce long-term therapeutic benefits. To test this hypothesis, we used nanoparticle-based delivery of simvastatin to inhibit plaque macrophage proliferation in apolipoprotein E deficient mice (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.