ArticleBioMed research international2015
Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Comparison and calibration of MP2RAGE quantitative T1 values to multi-TI inversion recovery T1 values.Magnetic resonance imaging · 2025Article
- Quantitative magnetization transfer imaging in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis.Brain communications · 2022Review
- Two Classes of T1 Hypointense Lesions in Multiple Sclerosis With Different Clinical Relevance.Frontiers in neurology · 2021Article
- Cognitive impairment in an animal model of multiple sclerosis and its amelioration by glatiramer acetate.Scientific reports · 2019Article
- Brain tissue volumes and relaxation rates in multiple sclerosis: implications for cognitive impairment.Journal of neurology · 2019Article
- Longitudinal analysis of white matter and cortical lesions in multiple sclerosis.NeuroImage. Clinical · 2019Article
- Multiple sclerosis and cognition: synaptic failure and network dysfunction.Nature reviews. Neuroscience · 2018Review
- Future Brain and Spinal Cord Volumetric Imaging in the Clinic for Monitoring Treatment Response in MS.Current treatment options in neurology · 2018Review
- Partial volume-aware assessment of multiple sclerosis lesions.NeuroImage. Clinical · 2018Article
- The Combined Quantification and Interpretation of Multiple Quantitative Magnetic Resonance Imaging Metrics Enlightens Longitudinal Changes Compatible with Brain Repair in Relapsing-Remitting Multiple Sclerosis Patients.Frontiers in neurology · 2017Article
- The Relationship between Psychosocial Factors and Cognition in Multiple Sclerosis.Behavioural neurology · 2017Article
- Brain imaging with synthetic MR in children: clinical quality assessment.Neuroradiology · 2016Article
- In Vivo Imaging of Human Neuroinflammation.ACS chemical neuroscience · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
Abstract
introductionLocal microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability.
methods36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3 T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2(*) relaxometry and magnetisation transfer imaging for lesion tissue characterization. Lesions were classified according to the extent of inflammation/neurodegeneration. A generalized linear model assessed the contribution of lesion groups to clinical performances.
resultsFour lesion groups were identified and characterized by (1) absence of significant alterations, (2) prevalent inflammation, (3) concomitant inflammation and microdegeneration, and (4) prevalent tissue loss. Groups 1, 3, 4 correlated with general disability (Adj-R (2) = 0.6; P = 0.0005), executive function (Adj-R (2) = 0.5; P = 0.004), verbal memory (Adj-R (2) = 0.4; P = 0.02), and attention (Adj-R (2) = 0.5; P = 0.002).
conclusionMulticontrast MRI provides a new approach to infer in vivo histopathology of plaques. Our results support evidence that neurodegeneration is the major determinant of patients' disability and cognitive dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.