ArticleAJNR. American journal of neuroradiology2015
Seizure Frequency Can Alter Brain Connectivity: Evidence from Resting-State fMRI.
Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 32 citations in OpenAlex.
- Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation.iScience · 2026Article
- Dual targeting of iNOS and Src tyrosine kinase as a superior therapeutic strategy against soman-induced long-term neurotoxicity: multimodal biomarker, imaging, and neurobehavioral outcome analyses.Acta neuropathologica communications · 2026Article
- Paroxysmal slow wave events as a diagnostic biomarker for epilepsy: Lessons from rural Zambia.Epilepsia · 2025Article
- Normative structural connectome constrains spreading transient brain activity in generalized epilepsy.BMC medicine · 2025Article
- The causal relationship of DTI phenotypes and epilepsy: A two sample mendelian randomization study.Epilepsia open · 2024Article
- Patient-specific structural connectivity informs outcomes of responsive neurostimulation for temporal lobe epilepsy.Epilepsia · 2022Article
- Thalamic deep brain stimulation paradigm to reduce consciousness: Cortico-striatal dynamics implicated in mechanisms of consciousness.PLoS computational biology · 2022Article
- Functional network connectivity imprint in febrile seizures.Scientific reports · 2022Article
- Effects of Neuromodulation on Excitatory-Inhibitory Neural Network Dynamics Depend on Network Connectivity Structure.Journal of nonlinear science · 2020Article
- Predicting the antiepileptic drug response by brain connectivity in newly diagnosed focal epilepsy.Journal of neurology · 2020Observational
- Bayesian framework for robust seed-based correlation analysis.Medical physics · 2019Article
- Relationship Between Seizure Frequency and Functional Abnormalities in Limbic Network of Medial Temporal Lobe Epilepsy.Frontiers in neurology · 2019Article
- Structural covariance networks relate to the severity of epilepsy with focal-onset seizures.NeuroImage. Clinical · 2018Article
- Regional cortical thickness changes accompanying generalized tonic-clonic seizures.NeuroImage. Clinical · 2018Article
- Can we predict drug response by volumes of the corpus callosum in newly diagnosed focal epilepsy?Brain and behavior · 2017Observational
- Recovery of resting brain connectivity ensuing mild traumatic brain injury.Frontiers in human neuroscience · 2015Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe frequency of seizures is an important factor that can alter functional brain connectivity. Analysis of this factor in patients with epilepsy is complex because of disease- and medication-induced confounders. Because patients with hot-water epilepsy generally are not on long-term drug therapy, we used seed-based connectivity analysis in these patients to assess connectivity changes associated with seizure frequency without confounding from antiepileptic drugs. MATERIALS AND
methodsResting-state fMRI data from 36 patients with hot-water epilepsy (18 with frequent seizures [>2 per month] and 18 with infrequent seizures [≤2 per month]) and 18 healthy age- and sex-matched controls were analyzed for seed-to-voxel connectivity by using 106 seeds. Voxel wise paired t-test analysis (P < .005, corrected for false-discovery rate) was used to identify significant intergroup differences between these groups.
resultsConnectivity analysis revealed significant differences between the 2 groups (P < .001). Patients in the frequent-seizure group had increased connectivity within the medial temporal structures and widespread areas of poor connectivity, even involving the default mode network, in comparison with those in the infrequent-seizure group. Patients in the infrequent-seizure group had focal abnormalities with increased default mode network connectivity and decreased left entorhinal cortex connectivity.
conclusionsThe results of this study suggest that seizure frequency can alter functional brain connectivity, which can be visualized by using resting-state fMRI. Imaging features such as diffuse network abnormalities, involvement of the default mode network, and recruitment of medial temporal lobe structures were seen only in patients with frequent seizures. Future studies in more common epilepsy groups, however, will be required to further establish this finding.
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