Trial reportThe British journal of psychiatry : the journal of mental science2016
Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.
Open access · bronzeAbstract readClinical TrialMulticenter Study
In one paragraph
Trial report in The British journal of psychiatry : the journal of mental science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders.Translational psychiatry · 2019Pooled it
- Trial
- Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.The British journal of psychiatry : the journal of mental science · 2016Trial
- Application and Mechanisms of Internet-Based Cognitive Behavioral Therapy (iCBT) in Improving Psychological State in Cancer Patients.Journal of Cancer · 2023Review
- Article
- Integrative DNA Methylation and Gene Expression Analysis of Cognitive Behavioral Therapy Response in Children and Adolescents with Obsessive-Compulsive Disorder; a Pilot Study.Pharmacogenomics and personalized medicine · 2021Article
- Genetics of response to cognitive behavior therapy in adults with major depression: a preliminary report.Molecular psychiatry · 2019Article
- Genetics of Anxiety Disorders.Current psychiatry reports · 2019Review
- The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- Psychotherapy and Genetic Neuroscience: An Emerging Dialog.Frontiers in genetics · 2018Review
- Epigenetic and Neural Circuitry Landscape of Psychotherapeutic Interventions.Psychiatry journal · 2017Review
- Article
- Article
- A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders.Psychotherapy and psychosomatics · 2016Article
- HPA AXIS RELATED GENES AND RESPONSE TO PSYCHOLOGICAL THERAPIES: GENETICS AND EPIGENETICS.Depression and anxiety · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 11 institutions in 9 countries.
Kathryn J LesterKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Susanna RobertsKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Robert KeersKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Jonathan R I ColemanKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Gerome BreenKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Chloe C Y WongKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Xiaohui XuKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Kristian ArendtKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Judith Blatter-MeunierKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Susan BögelsKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Peter CooperKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Cathy CreswellKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Einar R HeiervangKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Chantal HerrenKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Sanne M HogendoornKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Jennifer L HudsonKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Karen KrauseKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Heidi J LynehamKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Anna McKinnonKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Talia MorrisKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Maaike H NautaKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Ronald M RapeeKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Yasmin ReyKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Silvia SchneiderKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Sophie C SchneiderKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Wendy K SilvermanKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Patrick SmithKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Mikael ThastumKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Kerstin ThirlwallKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Polly WaiteKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Gro Janne WergelandKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
Thalia C EleyKathryn J. Lester, DPhil, School of Psychology, University of Sussex, and King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Susanna Roberts, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Robert Keers, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Jonathan R. I. Coleman, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Gerome Breen, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Chloe C. Y. Wong, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Xiaohui Xu, MD, King's College London, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Kristian Arendt, MSc, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands; Judith Blatter-Meunier, PhD, Department of Psychology, University of Basel, Basel, Switzerland; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, U
King's College London · GBUniversity of Reading · GBFlorida International University · USRuhr University Bochum · DEUniversity of Amsterdam · NLUniversity of Basel · CHUniversity of Bergen · NOUniversity of Oslo · NOUniversity of Sussex · GBUniversity of Sydney · AUYale University · US
Funding
Parent Mediation of Child Anxiety CBT OutcomeR01MH079943 · NIMH · FLORIDA INTERNATIONAL UNIVERSITY · PI PETTIT, JEREMY W · 2008 to 2012
$3.0MDepartment of Health PB-PG-0107-12042Department of Health PB-PG-0110-21190Department of Health RP_2014-04-018Medical Research Council 09/800/17Medical Research Council G0601020Medical Research Council G0601874Medical Research Council G0802326Medical Research Council G0802821Medical Research Council G0901874Medical Research Council G0901874/1Medical Research Council G1002011Medical Research Council MC_EX_G0802821Medical Research Council MR/J011762/1Medical Research Council MR/K021281/1Medical Research Council MR/K021281/2NIMH NIH HHS MH079943NIMH NIH HHS R01 MH079943
Abstract
backgroundWe previously reported an association between 5HTTLPR genotype and outcome following cognitive-behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome.
aimsTo replicate the association between 5HTTLPR and CBT outcome in child anxiety from the Genes for Treatment study (GxT Cohort 2, n = 829).
methodLogistic and linear mixed effects models were used to examine the relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both cohorts were performed.
resultsThere was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2. Mega-analyses identified a significant association between 5HTTLPR and remission from all anxiety disorders at follow-up (odds ratio 0.45, P = 0.014), but not primary anxiety disorder outcomes.
conclusionsThe association between 5HTTLPR genotype and CBT outcome did not replicate. Short-allele homozygotes showed more positive treatment outcomes, but with small, non-significant effects. Future studies would benefit from utilising whole genome approaches and large, homogenous samples.
Indexed as
Cognitive Behavioral TherapyGene-Environment InteractionAdolescentAllelesAnxiety DisordersChildChild, PreschoolFemaleGenotypeHumansMalePsychiatric Status Rating ScalesRemission InductionSerotonin Plasma Membrane Transport ProteinsTreatment OutcomeSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human
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